Graphene-Oxide-Decorated Microporous Polyetheretherketone with Superior Antibacterial Capability and In Vitro Osteogenesis for Orthopedic Implant

Ouyang, Ling, Deng, Yi, Yang, Lei, Shi, Xiuyuan, Dong, Taosheng, Tai, Youyi, Yang, Weizhong and Chen, Zhi-Gang (2018) Graphene-Oxide-Decorated Microporous Polyetheretherketone with Superior Antibacterial Capability and In Vitro Osteogenesis for Orthopedic Implant. Macromolecular bioscience, e1800036. doi:10.1002/mabi.201800036


Author Ouyang, Ling
Deng, Yi
Yang, Lei
Shi, Xiuyuan
Dong, Taosheng
Tai, Youyi
Yang, Weizhong
Chen, Zhi-Gang
Title Graphene-Oxide-Decorated Microporous Polyetheretherketone with Superior Antibacterial Capability and In Vitro Osteogenesis for Orthopedic Implant
Journal name Macromolecular bioscience   Check publisher's open access policy
ISSN 1616-5195
Publication date 2018-05-02
Sub-type Article (original research)
DOI 10.1002/mabi.201800036
Open Access Status Not yet assessed
Start page e1800036
Abstract Due to its similar elastic modulus of human bones, polyetheretherketone (PEEK) has been considered as an excellent cytocompatible material. However, the bioinertness, poor osteoconduction, and weak antibacterial activity of PEEK limit its wide applications in clinics. In this study, a facile strategy is developed to prepare graphene oxide (GO) modified sulfonated polyetheretherketone (SPEEK) (GO-SPEEK) through a simple dip-coating method. After detailed characterization, it is found that the GO closely deposits on the surface of PEEK, which is attributed to the π-π stacking interaction between PEEK and GO. Antibacterial tests reveal that the GO-SPEEK exhibits excellent suppression toward Escherichia coli. In vitro cell attachment, growth, differentiation, alkaline phosphatase activity, quantitative real-time polymerase chain reaction analyses, and calcium mineral deposition all illustrate that the GO-SPEEK substrate can significantly accelerate the proliferation and osteogenic differentiation of osteoblast-like MG-63 cells compared with those on PEEK and SPEEK groups. These results suggest that the GO-SPEEK has an improved antibacterial activity and cytocompatibility in vitro, showing that the developed GO-SPEEK has a great potential as the bioactive implant material in bone tissue engineering.
Keyword antibacterial activity
cytocompatibility
graphene oxide
osteogenic differentiation
polyetheretherketone
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Pubmed Import
 
Versions
Version Filter Type
Citation counts: Google Scholar Search Google Scholar
Created: Wed, 09 May 2018, 10:09:07 EST