Structure and dynamics of a gene network model incorporating small RNAs

Geard, N. L. and Wiles, J. H. (2003). Structure and dynamics of a gene network model incorporating small RNAs. In: R. Sarker, R. Reynolds and H. Abbass, 2003 Congress on Evolutionary Computation. 2003 Congress on Evolutionary Computation (CEC '03), Canberra, Australia, (199-206). 8-12 December 2003. doi:10.1109/CEC.2003.1299575


Author Geard, N. L.
Wiles, J. H.
Title of paper Structure and dynamics of a gene network model incorporating small RNAs
Conference name 2003 Congress on Evolutionary Computation (CEC '03)
Conference location Canberra, Australia
Conference dates 8-12 December 2003
Proceedings title 2003 Congress on Evolutionary Computation
Journal name Cec: 2003 Congress On Evolutionary Computation, Vols 1-4, Proceedings
Place of Publication Piscataway, NJ, U.S.A.
Publisher The Institute of Electrical and Electronics Engineers
Publication Year 2003
Sub-type Fully published paper
DOI 10.1109/CEC.2003.1299575
ISBN 0-7803-7804-0
Editor R. Sarker
R. Reynolds
H. Abbass
Volume 1
Start page 199
End page 206
Total pages 8
Language eng
Abstract/Summary As advances in molecular biology continue to reveal additional layers of complexity in gene regulation, computational models need to incorporate additional features to explore the implications of new theories and hypotheses. It has recently been suggested that eukaryotic organisms owe their phenotypic complexity and diversity to the exploitation of small RNAs as signalling molecules. Previous models of genetic systems are, for several reasons, inadequate to investigate this theory. In this study, we present an artificial genome model of genetic regulatory networks based upon previous work by Torsten Reil, and demonstrate how this model generates networks with biologically plausible structural and dynamic properties. We also extend the model to explore the implications of incorporating regulation by small RNA molecules in a gene network. We demonstrate how, using these signals, highly connected networks can display dynamics that are more stable than expected given their level of connectivity.
Subjects E1
280210 Simulation and Modelling
780100 Non-oriented Research
Keyword Artificial life
Evolutionary computation
Genetics
Macromolecules
Q-Index Code E1

 
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Created: Fri, 24 Aug 2007, 12:02:19 EST