Primary Role for CD4 T Lymphocytes in Recovery From Oropharyngeal Candidiasis

Farah, C. S., Elahi, S., Drysdale, K., Pang, G., Gotjamanos, T., Seymour, G. J., Clancy, R. L. and Ashman, R. B. (2002) Primary Role for CD4 T Lymphocytes in Recovery From Oropharyngeal Candidiasis. Infection and Immunity, 70 2: 724-731. doi:10.1128/IAI.70.2.724-731.2002

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Author Farah, C. S.
Elahi, S.
Drysdale, K.
Pang, G.
Gotjamanos, T.
Seymour, G. J.
Clancy, R. L.
Ashman, R. B.
Title Primary Role for CD4 T Lymphocytes in Recovery From Oropharyngeal Candidiasis
Journal name Infection and Immunity   Check publisher's open access policy
ISSN 1098-5522
1070-6313
Publication date 2002-02-01
Sub-type Article (original research)
DOI 10.1128/IAI.70.2.724-731.2002
Open Access Status File (Publisher version)
Volume 70
Issue 2
Start page 724
End page 731
Total pages 8
Place of publication Washington, DC, United States
Publisher American Society for Microbiology
Language eng
Abstract Oropharyngeal candidiasis is associated with defects in cell-mediated immunity and is commonly seen in human immunodeficiency virus positive individuals and AIDS patients. A model for oral candidiasis in T-cell-deficient BALB/c and CBA/CaH nu/nu mice was established. After inoculation with 108 Candida albicans yeasts, these mice displayed increased levels of oral colonization compared to euthymic control mice and developed a chronic oropharyngeal infection. Histopathological examination of nu/nu oral tissues revealed extensive hyphae penetrating the epithelium, with polymorphonuclear leukocyte microabscess formation. Adoptive transfer of either naive or immune lymphocytes into immunodeficient mice resulted in the recovery of these animals from the oral infection. Reconstitution of immunodeficient mice with naive CD4 but not CD8 T cells significantly decreased oral colonization compared to controls. Interleukin-12 and gamma interferon were detected in the draining lymph nodes of immunodeficient mice following reconstitution with naive lymphocytes. This study demonstrates the direct requirement for T lymphocytes in recovery from oral candidiasis and suggests that this is associated with the production of cytokines by CD4 T helper cells.
Keyword Candida
Mucosal
T cells
Cytokines
Q-Index Code C1
Additional Notes Originally published as Farah, C. S. and Elahi, S. and Drysdale, K. and Pang, G. and Gotjamanos, T. and Seymour, G. J. and Clancy, R. L. and Ashman, R. B. (2002) Primary Role for CD4 T Lymphocytes in Recovery From Oropharyngeal Candidiasis. Infection and Immunity 70(2):724-731. Copyright 2002 The American Society for Microbiology. All rights reserved.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Dentistry Publications
 
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Created: Fri, 11 Nov 2005, 10:00:00 EST by Robert Ashman on behalf of School of Dentistry