Brain tumour stem cells

Vescovi, Angelo L., Galli, Rossella and Reynolds, Brent A. (2006) Brain tumour stem cells. Nature Reviews Cancer, 6 6: 425-436. doi:10.1038/nrc1889

Author Vescovi, Angelo L.
Galli, Rossella
Reynolds, Brent A.
Title Brain tumour stem cells
Journal name Nature Reviews Cancer   Check publisher's open access policy
ISSN 1474-175X
Publication date 2006-06-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1038/nrc1889
Volume 6
Issue 6
Start page 425
End page 436
Total pages 12
Editor E. Hutchinson
N. McCarthy
S. Seton-Rogers
Place of publication London, UK
Publisher Nature Publishing Group
Language eng
Subject C1
320704 Cellular Nervous System
730104 Nervous system and disorders
Abstract The dogma that the genesis of new cells is a negligible event in the adult mammalian brain has long influenced our perception and understanding of the origin and development of CNS tumours. The discovery that new neurons and glia are produced throughout life from neural stem cells provides new possibilities for the candidate cells of origin of CNS neoplasias. The emerging hypothesis is that alterations in the cellular and genetic mechanisms that control adult neurogenesis might contribute to brain tumorigenesis, thereby allowing the identification of new therapeutic strategies.
Keyword Oncology
Fibroblast Growth Factor-2
Neural Progenitor Cells
Adult Human Hippocampus
Acute Myeloid-leukemia
Dentate Gyrus
Precursor Cells
Q-Index Code C1

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Excellence in Research Australia (ERA) - Collection
2007 Higher Education Research Data Collection
Queensland Brain Institute Publications
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Citation counts: TR Web of Science Citation Count  Cited 566 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 626 times in Scopus Article | Citations
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Created: Wed, 15 Aug 2007, 21:06:33 EST