Idiopathic sclerosing orbital inflammation

Hsuan, James D., Dinesh,Selva, McNab, Alan A., Sullivan, Timothy J., Saeed, Peerooz and O'Donnell, Brett A. (2006) Idiopathic sclerosing orbital inflammation. Archives of Ophthalmology, 124 9: 1244-1250. doi:10.1001/archopht.124.9.1244

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Author Hsuan, James D.
McNab, Alan A.
Sullivan, Timothy J.
Saeed, Peerooz
O'Donnell, Brett A.
Title Idiopathic sclerosing orbital inflammation
Journal name Archives of Ophthalmology   Check publisher's open access policy
ISSN 2168-6165
Publication date 2006-01-01
Year available 2006
Sub-type Article (original research)
DOI 10.1001/archopht.124.9.1244
Open Access Status File (Publisher version)
Volume 124
Issue 9
Start page 1244
End page 1250
Total pages 7
Place of publication Chicago, IL, United States
Publisher American Medical Association
Language eng
Abstract Objective: To perform a multicenter review of the clinical features and treatment of 31 patients with idiopathic sclerosing orbital inflammation. Methods: We included all patients with histologically confirmed idiopathic sclerosing orbital inflammation from 5 regional orbital centers. We reviewed the case notes to determine the clinical presentation, diagnostic features, and response to treatment. The main outcome measures were duration and nature of symptoms, anatomical location of disease, histopathological findings, treatment modalities, treatment efficacy and adverse effects, and final clinical status. Results: We included 13 male and 18 female patients ranging in age from 7 to 83 years. The average duration of symptoms at presentation was 13.4 months. There was a predilection for the lateral and superior quadrants. Thirteen patients had apical disease, and 4 had extraorbital involvement. Histopathological findings invariably showed sclerosis associated with a sparse mixed cellular infiltrate. Twenty- seven patients were treated with oral prednisolone, response to which was good in 9 patients, partial in 11, and poor in 7. Six patients were treated with a second- line immunosuppressive agent, and 6 received radiotherapy. The response to radiotherapy was generally poor. Conclusions: Idiopathic sclerosing orbital inflammation is a rare condition that can be difficult to diagnose and manage. Early intervention with immunosuppression in the form of corticosteroids combinedwith secondline agents can result in control and even regression of the disease.
Keyword Ophthalmology
Retroperitoneal Fibrosis
Intracranial Extension
Multifocal Fibrosclerosis
Q-Index Code C1
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2007 Higher Education Research Data Collection
Institute for Molecular Bioscience - Publications
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Citation counts: TR Web of Science Citation Count  Cited 41 times in Thomson Reuters Web of Science Article | Citations
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Created: Wed, 15 Aug 2007, 20:57:08 EST