The transcriptional coactivator Querkopf controls adult neurogenesis

Merson, T. D., Dixon, M. P., Collin, C., Rietze, R. L., Bartlett, P. F., Thomas, T. and Voss, A. K. (2006) The transcriptional coactivator Querkopf controls adult neurogenesis. Journal of Neuroscience, 26 44: 11359-11370. doi:10.1523/JNEUROSCI.2247-06.2006

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Author Merson, T. D.
Dixon, M. P.
Collin, C.
Rietze, R. L.
Bartlett, P. F.
Thomas, T.
Voss, A. K.
Title The transcriptional coactivator Querkopf controls adult neurogenesis
Journal name Journal of Neuroscience   Check publisher's open access policy
ISSN 0270-6474
Publication date 2006-01-01
Sub-type Article (original research)
DOI 10.1523/JNEUROSCI.2247-06.2006
Open Access Status File (Publisher version)
Volume 26
Issue 44
Start page 11359
End page 11370
Total pages 12
Editor D. C. Van Essen
Place of publication Washington
Publisher Society for Neuroscience
Collection year 2006
Language eng
Subject C1
320702 Central Nervous System
730104 Nervous system and disorders
Abstract The adult mammalian brain maintains populations of neural stem cells within discrete proliferative zones. Understanding of the molecular mechanisms regulating adult neural stem cell function is limited. Here, we show that MYST family histone acetyltransferase Querkopf (Qkf, Myst4, Morf)-deficient mice have cumulative defects in adult neurogenesis in vivo, resulting in declining numbers of olfactory bulb interneurons, a population of neurons produced in large numbers during adulthood. Qkf-deficient mice have fewer neural stem cells and fewer migrating neuroblasts in the rostral migratory stream. Qkf gene expression is strong in the neurogenic subventricular zone. A population enriched in multipotent cells can be isolated from this region on the basis of Qkf gene expression. Neural stem cells/progenitor cells isolated from Qkf mutant mice exhibited a reduced self-renewal capacity and a reduced ability to produce differentiated neurons. Together, our data show that Qkf is essential for normal adult neurogenesis.
Keyword Neurosciences
Qkf
Transcription
Chromatin
Neural Stem Cells
Adult Neurogenesis
Neuroblasts
Neural Stem-cells
Mouse Olfactory-bulb
Zinc-finger Protein
Mammalian Brain
Histone Acetyltransferase
Subventricular Zone
Neuronal Migration
Forebrain
Leukemia
Proliferation
Q-Index Code C1

 
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Created: Wed, 15 Aug 2007, 20:53:49 EST