Optimal crossover designs for logistic regression models in pharmacodynamics

Waterhouse, T. H., Eccleston, J. A. and Duffull, S. B. (2006) Optimal crossover designs for logistic regression models in pharmacodynamics. Journal of Biopharmaceutical Statistics, 16 6: 881-894. doi:10.1080/10543400600851880

Author Waterhouse, T. H.
Eccleston, J. A.
Duffull, S. B.
Title Optimal crossover designs for logistic regression models in pharmacodynamics
Journal name Journal of Biopharmaceutical Statistics   Check publisher's open access policy
ISSN 1054-3406
Publication date 2006-01-01
Sub-type Article (original research)
DOI 10.1080/10543400600851880
Volume 16
Issue 6
Start page 881
End page 894
Total pages 14
Editor Shein-Chung Chow
Place of publication Philadelphia, PA, United States
Publisher Taylor & Francis
Language eng
Subject C1
230203 Statistical Theory
730299 Public health not elsewhere classified
Abstract Pharmacodynamics (PD) is the study of the biochemical and physiological effects of drugs. The construction of optimal designs for dose-ranging trials with multiple periods is considered in this paper, where the outcome of the trial (the effect of the drug) is considered to be a binary response: the success or failure of a drug to bring about a particular change in the subject after a given amount of time. The carryover effect of each dose from one period to the next is assumed to be proportional to the direct effect. It is shown for a logistic regression model that the efficiency of optimal parallel (single-period) or crossover (two-period) design is substantially greater than a balanced design. The optimal designs are also shown to be robust to misspecification of the value of the parameters. Finally, the parallel and crossover designs are combined to provide the experimenter with greater flexibility.
Keyword Binary data
Crossover designs
Logistic regression
Optimal design
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
2007 Higher Education Research Data Collection
School of Pharmacy Publications
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Citation counts: TR Web of Science Citation Count  Cited 6 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 5 times in Scopus Article | Citations
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Created: Wed, 15 Aug 2007, 20:27:52 EST