The complexity of p53 stabilization and activation

Lavin, M. F. and Gueven, N. (2006) The complexity of p53 stabilization and activation. Cell Death And Differentiation, 13 6: 941-950. doi:10.1038/sj.cdd.4401925


Author Lavin, M. F.
Gueven, N.
Title The complexity of p53 stabilization and activation
Journal name Cell Death And Differentiation   Check publisher's open access policy
ISSN 1350-9047
Publication date 2006-01-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1038/sj.cdd.4401925
Volume 13
Issue 6
Start page 941
End page 950
Total pages 10
Editor G. Melino
Place of publication London, U.K.
Publisher Nature Publishing Group
Collection year 2006
Language eng
Subject C1
320305 Medical Biochemistry - Proteins and Peptides
730108 Cancer and related disorders
CX
Abstract A number of proteins are activated by stress stimuli but none so spectacularly or with the degree of complexity as the tumour suppressor p53 (human p53 gene or protein). Once stabilized, p53 is responsible for the transcriptional activation of a series of proteins involved in cell cycle control, apoptosis and senescence. This protein is present at low levels in resting cells but after exposure to DNA-damaging agents and other stress stimuli it is stabilized and activated by a series of post-translational modifications that free it from MDM2 (mouse double minute 2 but used interchangeably to denote human also), a ubiquination ligase that ubiquitinates it prior to proteasome degradation. The stability of p53 is also influenced by a series of other interacting proteins. In this review, we discuss the post-translational modifications to p53 in response to different stresses and the consequences of these changes.
Keyword Biochemistry & Molecular Biology
Cell Biology
P53
Cellular Stress
Post-translational Modifications
Other Factors
Cell Cycle Control
Damage-induced Phosphorylation
Atm-dependent Phosphorylation
Ubiquitin-protein Ligase
P53-mediated G(1) Arrest
Dna-damage
Ionizing-radiation
Transcriptional Activity
Tumor-suppressor
In-vivo
Poly(adp-ribose) Polymerase-1
Q-Index Code C1
Additional Notes This document is a journal review.

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Excellence in Research Australia (ERA) - Collection
2007 Higher Education Research Data Collection
School of Medicine Publications
 
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Created: Wed, 15 Aug 2007, 20:07:30 EST