Transdermal drug delivery: Basic principles for the veterinarian

Mills, P. C. and Cross, S. E. (2006) Transdermal drug delivery: Basic principles for the veterinarian. Veterinary Journal, 172 2: 218-233. doi:10.1016/j.tvjl.2005.09.006


Author Mills, P. C.
Cross, S. E.
Title Transdermal drug delivery: Basic principles for the veterinarian
Journal name Veterinary Journal   Check publisher's open access policy
ISSN 1090-0233
Publication date 2006-09-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.tvjl.2005.09.006
Open Access Status Not yet assessed
Volume 172
Issue 2
Start page 218
End page 233
Total pages 16
Editor A.J. Higgins
Place of publication UK
Publisher W.B. Saunders Co. Ltd.
Language eng
Subject C1
300512 Pharmacology
780105 Biological sciences
CX
Abstract The use of topical pharmaceutical formulations is increasingly popular in veterinary medicine. A potential concern is that not all formulations are registered for the intended species, yet current knowledge strongly suggests that simple extrapolation of transdermal drug pharmacokinetics and pharmacodynamics between species, including humans, cannot be done. In this review, an overview is provided of the underlying basic principles determining the movement of topically applied molecules into and through the skin. Various factors that may affect transdermal drug penetration between species, between individuals of a particular species and regional differences in an individual are also discussed. A good understanding of the basic principles of transdermal drug delivery is critical to avoid adverse effects or lack of efficacy when applying topical formulations in veterinary medicine. (c) 2005 Elsevier Ltd. All rights reserved.
Keyword Transdermal
topical
pharmacokinetics
drug delivery
skin
Veterinary Sciences
Topical
Pharmacokinetics
Drug Delivery
Skin
Human Stratum-corneum
Skin In-vitro
Underlying Tissue Pharmacokinetics
Topically Applied Hydrocortisone
Human Epidermal Membrane
Blood-flow Measurements
Hairless Mouse Skin
Percutaneous-absorption
Penetration Enhancers
Iontophoretic Delivery
Q-Index Code C1
Additional Notes This document is a journal review.

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Excellence in Research Australia (ERA) - Collection
2007 Higher Education Research Data Collection
School of Medicine Publications
 
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Created: Wed, 15 Aug 2007, 20:06:38 EST