Regional differences in the in vitro penetration of hydrocortisone through equine skin

Mills, PC and Cross, SE (2006) Regional differences in the in vitro penetration of hydrocortisone through equine skin. Journal of Veterinary Pharmacology And Therapeutics, 29 1: 25-30. doi:10.1111/j.1365-2885.2006.00705.x


Author Mills, PC
Cross, SE
Title Regional differences in the in vitro penetration of hydrocortisone through equine skin
Journal name Journal of Veterinary Pharmacology And Therapeutics   Check publisher's open access policy
ISSN 0140-7783
Publication date 2006-01-01
Sub-type Article (original research)
DOI 10.1111/j.1365-2885.2006.00705.x
Open Access Status Not yet assessed
Volume 29
Issue 1
Start page 25
End page 30
Total pages 6
Editor Jim E. Riviere; Peter Lees
Place of publication UK
Publisher Blackwell Publishing Ltd.
Language eng
Subject C1
300512 Pharmacology
780105 Biological sciences
Abstract Little is known about the transdermal penetration of hydrocortisone in the horse and, although commercial formulations containing hydrocortisone are registered for topical use in the horse, there have been no studies investigating the movement of this glucocorticoid through different regions of equine skin. Skin was harvested from the thorax, groin and leg (dorsal metacarpal) regions of five Thoroughbred geldings and frozen (-20 degrees C) until required. Defrosted skin was placed in Franz-type diffusion cells and the amount of radiolabelled (H-3) hydrocortisone, in a saturated solution of unlabelled hydrocortisone in 50% ethanol (w/w), which penetrated through and remained within skin samples was measured over 24 h. Significantly higher (P < 0.001) maximum flux (J(max); mol/cm(2)/h) was measured when hydrocortisone was applied to skin from the leg, compared to thorax and groin, although significantly less hydrocortisone (P < 0.001) was retained within skin from the leg at 24 h. Topical application of hydrocortisone in a vehicle containing ethanol would penetrate faster through leg skin from the lower leg when compared with the thorax or groin, which depending on cutaneous blood flow, may result in higher systemic drug concentrations or greater efficiency in treating local inflamed tissue.
Keyword In Vitro
Penetration
Hydrocortisone
Equine Skin
Pharmacology & Pharmacy
Veterinary Sciences
Percutaneous-absorption
Transdermal Delivery
Transfollicular Routes
Narcotic Analgesics
Propylene-glycol
Stratum-corneum
Canine Skin
Ethanol
Permeation
Water
Q-Index Code C1
Institutional Status UQ

 
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Created: Wed, 15 Aug 2007, 20:05:57 EST