Relationship between myocardial perfusion and dysfunction in diabetic cardiomyopathy: A study of quantitative contrast echocardiography and strain rate imaging

Moir, S, Hanekom, L, Fang, ZY, Haluska, B, Wong, C, Burgess, M and Marwick, TH (2006) Relationship between myocardial perfusion and dysfunction in diabetic cardiomyopathy: A study of quantitative contrast echocardiography and strain rate imaging. Heart, 92 10: 1414-1419. doi:10.1136/hrt.2005.079350


Author Moir, S
Hanekom, L
Fang, ZY
Haluska, B
Wong, C
Burgess, M
Marwick, TH
Title Relationship between myocardial perfusion and dysfunction in diabetic cardiomyopathy: A study of quantitative contrast echocardiography and strain rate imaging
Journal name Heart   Check publisher's open access policy
ISSN 1355-6037
1468-201X
Publication date 2006-10-01
Sub-type Article (original research)
DOI 10.1136/hrt.2005.079350
Volume 92
Issue 10
Start page 1414
End page 1419
Total pages 6
Editor R. J. Hall
Place of publication London, U.K.
Publisher BMJ Publishing Group
Language eng
Subject C1
321003 Cardiology (incl. Cardiovascular Diseases)
730106 Cardiovascular system and diseases
1102 Cardiovascular Medicine and Haematology
Abstract Objective: To use quantitative myocardial contrast echocardiography (MCE) and strain rate imaging (SRI) to assess the role of microvascular disease in subclinical diabetic cardiomyopathy. Methods: Stress MCE and SRI were performed in 48 patients (22 with type II diabetes mellitus (DM) and 26 controls), all with normal left ventricular systolic function and no obstructive coronary disease by quantitative coronary angiography. Real-time MCE was acquired in three apical views at rest and after combined dipyridamole-exercise stress. Myocardial blood flow (MBF) was quantified in the 10 mid- and apical cardiac segments at rest and after stress. Resting peak systolic strain rate (SR) and peak systolic strain (epsilon) were calculated in the same 10 myocardial segments. Results: The DM and control groups were matched for age, sex and other risk factors, including hypertension. The DM group had higher body mass index and left ventricular mass index. Quantitative SRI analysis was possible in all patients and quantitative MCE in 46 (96%). The mean e, SR and MBF reserve were all significantly lower in the DM group than in controls, with diabetes the only independent predictor of each parameter. No correlation was seen between MBF and SR (r = -0.01, p = 0.54) or between MBF and epsilon ( r = -0.20, p = 0.20). Conclusions: Quantitative MCE shows that patients with diabetes but no evidence of obstructive coronary artery disease have impaired MBF reserve, but abnormal transmural flow and subclinical longitudinal myocardial dysfunction are not related.
Keyword Cardiac & cardiovascular systems
Coronary flow reserve
Artery-disease
Blood-flow
Real-time
Exercise echocardiography
Stenosis severity
Heart-disease
Mellitus
Quantification
Humans
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
2007 Higher Education Research Data Collection
School of Medicine Publications
 
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Created: Wed, 15 Aug 2007, 19:58:07 EST