The diabetic myocardium

Marwick, T. H. (2006) The diabetic myocardium. Current Diabetes Reports, 6 1: 36-41. doi:10.1007/s11892-006-0049-0


Author Marwick, T. H.
Title The diabetic myocardium
Journal name Current Diabetes Reports   Check publisher's open access policy
ISSN 1534-4827
Publication date 2006-01-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1007/s11892-006-0049-0
Open Access Status Not yet assessed
Volume 6
Issue 1
Start page 36
End page 41
Total pages 6
Editor E. Horton
Place of publication USA
Publisher Current Science Inc
Subject CX
321003 Cardiology (incl. Cardiovascular Diseases)
730106 Cardiovascular system and diseases
Abstract Heart failure and diabetes mellitus are frequently associated, with diabetes potentiating the development of heart failure after other myocardial insults. This review documents the evidence in support of a specific primary myocardial disease in diabetes. The strongest clinical evidence relates to the detection of otherwise unexplained diastolic dysfunction in apparently healthy diabetic subjects, but recent studies with sensitive echocardiographic markers have shown systolic disturbances as well. The mechanism of this myocardial disease is multifactorial, with contributions from metabolic effects on the myocyte, structural changes in the myocardium and interstitium, autonomic neuropathy, and perhaps coronary vascular disease. The common pathway appears to be related to glycemic control and new evidence suggests better metabolic control to be beneficial, as well as angiotensin-converting enzyme inhibition and cross-link breakers.
Q-Index Code CX
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Excellence in Research Australia (ERA) - Collection
School of Medicine Publications
 
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Created: Wed, 15 Aug 2007, 19:55:32 EST