The lipid core peptide system in vaccine delivery

Toth, I., Moyle, P. M., Karpati, L., Horvath, A., Olive, C. and Good, M. F. (2006). The lipid core peptide system in vaccine delivery. In: International Congress Series: Streptococci - New Insights Into an Old Enemy - Proceedings of the XVIth Lancefield International Symposium on Streptococci and Streptococcal Diseases, held in Palm Cove, Australia between 25 and 29 September, 2005. XVIth Lancefield International Symposium on Streptococci and Streptococcal Diseases, Palm Cove, Australia, (307-310). 25 and 29 September 2005. doi:10.1016/j.ics.2005.11.057


Author Toth, I.
Moyle, P. M.
Karpati, L.
Horvath, A.
Olive, C.
Good, M. F.
Title of paper The lipid core peptide system in vaccine delivery
Conference name XVIth Lancefield International Symposium on Streptococci and Streptococcal Diseases
Conference location Palm Cove, Australia
Conference dates 25 and 29 September 2005
Proceedings title International Congress Series: Streptococci - New Insights Into an Old Enemy - Proceedings of the XVIth Lancefield International Symposium on Streptococci and Streptococcal Diseases, held in Palm Cove, Australia between 25 and 29 September, 2005   Check publisher's open access policy
Place of Publication Amsterdam, The Netherlands
Publisher Excerpta Medica Foundation
Publication Year 2006
Sub-type Fully published paper
DOI 10.1016/j.ics.2005.11.057
Open Access Status Not Open Access
ISSN 0531-5131
Volume 1289
Start page 307
End page 310
Total pages 4
Language eng
Formatted Abstract/Summary
Lipid core peptide (LCP)-based group A streptococcal (GAS) vaccines incorporating numerous GAS M-protein epitopes have been synthesized in high purity. The LCP system incorporates adjuvant, carrier, and antigens into a single well-characterized construct. A tetra-epitopic vaccine, incorporating a highly conserved GAS M-protein C-terminal epitope and three strain-specific epitopes from the variable GAS M-protein N-terminal region, was synthesized using stepwise solid-phase peptide synthesis. Immunization of mice with this construct yielded high IgG antibody responses without the use of traditional adjuvants.
© 2005 Elsevier B.V. All rights reserved.
Subjects C1
250302 Biological and Medical Chemistry
730101 Infectious diseases
Keyword Immunoadjuvants
Vaccine delivery
Vaccine design
Streptococcal infection
LCP system
Q-Index Code C1

 
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Created: Wed, 15 Aug 2007, 19:50:55 EST