White and gray matter development in human fetal, newborn and pediatric brains

Huang, Hao, Zhang, Jiangyang, Wakana, Setsu, Zheng, Weihong, Ren,Tianbo, Richards, Linda J., Yarowsky, Paul, Donohue, Pamela, Graham, Ernest, Van Zijl, Peter C.M. and Mori, Susumu (2006) White and gray matter development in human fetal, newborn and pediatric brains. Neuroimage, 33 1: 27-38. doi:10.1016/j.neuroimage.2006.06.009

Author Huang, Hao
Zhang, Jiangyang
Wakana, Setsu
Zheng, Weihong
Richards, Linda J.
Yarowsky, Paul
Donohue, Pamela
Graham, Ernest
Van Zijl, Peter C.M.
Mori, Susumu
Title White and gray matter development in human fetal, newborn and pediatric brains
Journal name Neuroimage   Check publisher's open access policy
ISSN 1053-8119
Publication date 2006-10-15
Year available 2006
Sub-type Article (original research)
DOI 10.1016/j.neuroimage.2006.06.009
Open Access Status Not yet assessed
Volume 33
Issue 1
Start page 27
End page 38
Total pages 12
Editor J. C. Mazziotta
Place of publication San Diego
Publisher Academic Press Inc Elsevier Science
Language eng
Subject C1
270106 Cell Development (incl. Cell Division and Apoptosis)
730104 Nervous system and disorders
Abstract Brain anatomy is characterized by dramatic growth from the end of the second trimester through the neonatal stage. The characterization of normal axonal growth of the white matter tracts has not been well-documented to date and could provide important clues to understanding the extensive inhomogeneity of white matter injuries in cerebral palsy (CP) patients. However, anatomical studies of human brain development during this period are surprisingly scarce and histology-based atlases have become available only recently. Diffusion tensor magnetic resonance imaging (DTMRI) can reveal detailed anatomy of white matter. We acquired diffusion tensor images (DTI) of postmortem fetal brain samples and in vivo neonates and children. Neural structures were annotated in two-dimensional (2D) slices, segmented, measured, and reconstructed three-dimensionally (3D). The growth status of various white matter tracts was evaluated on cross-sections at 19-20 gestational weeks, and compared with 0-month-old neonates and 5- to 6-year-old children. Limbic, commissural, association, and projection white matter tracts and gray matter structures were illustrated in 3D and quantitatively characterized to assess their dynamic changes. The overall pattern of the time courses for the development of different white matter is that limbic fibers develop first and association fibers last and commissural and projection fibers are forming from anterior to posterior part of the brain. The resultant DTNIRI-based 3D human brain data will be a valuable resource for human brain developmental study and will provide reference standards for diagnostic radiology of premature newborns. (c) 2006 Elsevier Inc. All rights reserved.
Keyword DTI
brain development
Diffusion Anisotropy
Periventricular Leukomalacia
Laminar Organization
Axonal Projections
Water Diffusion
Q-Index Code C1
Grant ID RR15241
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Faculty of Science Publications
Excellence in Research Australia (ERA) - Collection
2007 Higher Education Research Data Collection
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Citation counts: TR Web of Science Citation Count  Cited 186 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 207 times in Scopus Article | Citations
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Created: Wed, 15 Aug 2007, 19:29:24 EST