Ultra-endurance exercise and oxidative damage: Implications for cardiovascular health

Knez, W.L., Coombes, J. S. and Jenkins, D. G. (2006) Ultra-endurance exercise and oxidative damage: Implications for cardiovascular health. Sports Medicine, 36 5: 429-441. doi:10.2165/00007256-200636050-00005


Author Knez, W.L.
Coombes, J. S.
Jenkins, D. G.
Title Ultra-endurance exercise and oxidative damage: Implications for cardiovascular health
Journal name Sports Medicine   Check publisher's open access policy
ISSN 0112-1642
Publication date 2006-01-01
Sub-type Article (original research)
DOI 10.2165/00007256-200636050-00005
Open Access Status Not Open Access
Volume 36
Issue 5
Start page 429
End page 441
Total pages 13
Editor J.N. Shanahan
Place of publication Auckland, N.Z.
Publisher Adis International
Language eng
Subject C1
321401 Exercise Physiology
321003 Cardiology (incl. Cardiovascular Diseases)
730106 Cardiovascular system and diseases
1106 Human Movement and Sports Science
Abstract At least 30 minutes of moderate-intensity physical activity accumulated on most, preferably all days is considered the minimum level necessary to reduce the risk of developing cardiovascular disease. Despite an unclear explanation, some epidemiological data paradoxically suggest that a very high volume of exercise is associated with a decrease in cardiovascular health. Although ultra-endurance exercise training has been shown to increase antioxidant defences (and therefore confer a protective effect against oxidative stress), an increase in oxidative stress may contribute to the development of atherosclerosis via oxidative modification of low-density lipoprotein (LDL). Research has also shown that ultra-endurance exercise is associated with acute cardiac dysfunction and injury, and these may also be related to an increase in free radical production. Longitudinal studies are needed to assess whether antioxidant defences are adequate to prevent LDL oxidation that may occur as a result of increased free radical production during very high volumes of exercise. In addition, this work will assist in understanding the accrued effect of repeated ultra-endurance exercise-induced myocardial damage.
Keyword Sport sciences
Low-density-lipoprotein
Harvard alumni health
Induced muscle damage
Lipid-peroxidation
Physical-activity
Free-radicals
Xanthine-oxidase
Vitamin-e
Antioxidant supplementation
Tissue destruction
Q-Index Code C1
Institutional Status Non-UQ

 
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Created: Wed, 15 Aug 2007, 19:26:53 EST