The novel cytoskeleton-associated protein Neuronal protein 22: Elevated expression in the developing rat brain

Depaz, Iris M. and Wilce, Peter A. (2006) The novel cytoskeleton-associated protein Neuronal protein 22: Elevated expression in the developing rat brain. Brain Research, 1081 1: 59-64. doi:10.1016/j.brainres.2006.01.126


Author Depaz, Iris M.
Wilce, Peter A.
Title The novel cytoskeleton-associated protein Neuronal protein 22: Elevated expression in the developing rat brain
Journal name Brain Research   Check publisher's open access policy
ISSN 0006-8993
1872-6240
Publication date 2006-01-01
Sub-type Article (original research)
DOI 10.1016/j.brainres.2006.01.126
Volume 1081
Issue 1
Start page 59
End page 64
Total pages 6
Place of publication Amsterdam, Netherlands
Publisher Elsevier
Language eng
Subject C1
270107 Cell Neurochemistry
730104 Nervous system and disorders
Abstract Neuronal development and process targeting is mediated by proteins of the cytoskeleton. However, the signaling pathways underlying these mechanisms are complex and have not yet been fully elucidated. Neuronal protein 22 (NP22) has been identified as a cytoskeleton-associated protein. It colocalizes with microtubules and actin, the two major components of the cytoskeleton. It contains numerous signaling motifs and induces process formation in non-neuronal cells. Expression of rat NP22 (rNP22) rises incrementally at specific time points during brain development, with the greatest elevation occurring during synaptogenesis in the rat brain. its neuronal localization is primarily at the plasma membrane of the soma in the embryonic brain and progresses into homogeneous expression in the postnatal rat brain. Data suggest that NP22 may play a role in mediating the molecular events governing development of the neuronal architecture. Furthermore, its sustained expression in postnatal brain implies a function in the maintenance of neuronal morphology.
Keyword Neuronal Protein 22
Actin
Microtubule
Process Formation
Cytoskeleton
Plasticity
Neurosciences
Alcoholic Brain
Smooth-muscle
Growth Cones
Pc12 Cells
Microtubules
Binding
Gtpase
Kinase
Hnp22
Q-Index Code C1
Institutional Status UQ

 
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Created: Wed, 15 Aug 2007, 19:22:08 EST