The mononuclear phagocyte system

Hume, D. A. (2006) The mononuclear phagocyte system. Current Opinion In Immunology, 18 1: 49-53. doi:10.1016/j.coi.2005.11.008


Author Hume, D. A.
Title The mononuclear phagocyte system
Journal name Current Opinion In Immunology   Check publisher's open access policy
ISSN 0952-7915
Publication date 2006-01-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.coi.2005.11.008
Volume 18
Issue 1
Start page 49
End page 53
Total pages 5
Editor J. Diebold
Place of publication London
Publisher Current Biology Ltd
Language eng
Subject C1
320202 Cellular Immunology
730102 Immune system and allergy
Abstract The mononuclear phagocyte system (MPS) has been defined as a family of cells comprising bone marrow progenitors, blood monocytes and tissue macrophages. Macrophages are a major cell population in most of the tissues in the body, and their numbers increase further in inflammation, wounding and malignancy. Their trophic roles for other cell types in development and homeostasis are becoming increasingly evident. The receptor for macrophage colony-stimulating factor (CSF-1R) is expressed in a large proportion of cells considered to be mononuclear phagocytes, including antigen-presenting dendritic cells, which can be considered a specialized adaptive state rather than a separate lineage. The unity of the MPS is challenged by evidence that there is a separate embryonic phagocyte lineage, by the transdifferentiation and fusion of MPS cells with other cell types, and by evidence of local renewal of tissue macrophage populations as opposed to monocyte recruitment. The concept of the MPS may have partly outlived its usefulness.
Keyword Immunology
Stimulating Factor-1 Receptor
Skeletal-muscle
Dendritic Cells
Myelomonocytic Cells
Macrophage Fusion
Dc-stamp
T-cells
Monocytes
Mouse
Mice
Q-Index Code C1

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: 2007 Higher Education Research Data Collection
Institute for Molecular Bioscience - Publications
 
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Created: Wed, 15 Aug 2007, 19:21:58 EST