The makings of maleness: towards an integrated view of male sexual development

Wilhelm, Dagmar and Koopman, Peter (2006) The makings of maleness: towards an integrated view of male sexual development. Nature Reviews Genetics, 7 8: 620-631. doi:10.1038/nrg1903


Author Wilhelm, Dagmar
Koopman, Peter
Title The makings of maleness: towards an integrated view of male sexual development
Journal name Nature Reviews Genetics   Check publisher's open access policy
ISSN 1471-0056
Publication date 2006-01-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1038/nrg1903
Volume 7
Issue 8
Start page 620
End page 631
Total pages 12
Place of publication London, U.K.
Publisher Nature Publishing Group
Collection year 2006
Language eng
Subject C1
270205 Genetic Development (incl. Sex Determination)
780105 Biological sciences
1103 Clinical Sciences
Abstract As the mammalian embryo develops, it must engage one of the two distinct programmes of gene activity, morphogenesis and organogenesis that characterize males and females. In males, sexual development hinges on testis determination and differentiation, but also involves many coordinated transcriptional, signalling and endocrine networks that underpin the masculinization of other organs and tissues, including the brain. Here we bring together current knowledge about these networks, identify gaps in the overall picture, and highlight the known defects that lead to disorders of male sexual development.
Keyword Testis-determining Gene
Mullerian Duct Syndrome
Steroidogenic Factor-i
Desert-hedgehog Gene
Sry-related Gene
Cell-migration
Growth-factor
Germ-cells
Gonadal-dysgenesis
Point Mutations
Q-Index Code C1

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Excellence in Research Australia (ERA) - Collection
2007 Higher Education Research Data Collection
Institute for Molecular Bioscience - Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 116 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 130 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Wed, 15 Aug 2007, 19:21:45 EST