Synthesis and characterization of Pd(II) and Pt(II) complexes with triazolopyrimidine derivatives: The crystal structure of [Pd2L2Cl4] where L=5,7-dimethyl-1,2,4-triazolo[1,5-a]pyrimidine

Lekkas, Nikos, Hadjiliadis, Nick, Garoufis, Achilleas, Kobe, Joseph, Bernhardt, Paul V. and Tiekink, Edward R.T. (2006) Synthesis and characterization of Pd(II) and Pt(II) complexes with triazolopyrimidine derivatives: The crystal structure of [Pd2L2Cl4] where L=5,7-dimethyl-1,2,4-triazolo[1,5-a]pyrimidine. Inorganica Chimica Acta, 359 13: 4297-4303. doi:10.1016/j.ica.2006.06.016


Author Lekkas, Nikos
Hadjiliadis, Nick
Garoufis, Achilleas
Kobe, Joseph
Bernhardt, Paul V.
Tiekink, Edward R.T.
Title Synthesis and characterization of Pd(II) and Pt(II) complexes with triazolopyrimidine derivatives: The crystal structure of [Pd2L2Cl4] where L=5,7-dimethyl-1,2,4-triazolo[1,5-a]pyrimidine
Journal name Inorganica Chimica Acta   Check publisher's open access policy
ISSN 0020-1693
Publication date 2006-01-01
Sub-type Article (original research)
DOI 10.1016/j.ica.2006.06.016
Open Access Status Not Open Access
Volume 359
Issue 13
Start page 4297
End page 4303
Total pages 7
Place of publication Lausanne
Publisher Elsevier Science Sa
Language eng
Subject C1
250201 Transition Metal Chemistry
780103 Chemical sciences
Abstract The Pd(II) and Pt(II) complexes with triazolopyrimidine C-nucleosides L-1 (5,7-dimethyl-3-(2',3',5'-tri-O-benzoyl-beta-D-ribofuranosyl-s-triazolo)[4,3-a]pyrimidine), L-2 (5,7-dimethyl-3-beta-D-ribofuranosyl-s-triazolo [4,3-a]pyrimidine) and L-3 (5,7-dimethyl[1,5-a]-s-triazolopyrimidine), [Pd(en)(L-1)](NO3)(2), (Pd(bpy)(L-1)](NO3)(2), cis-Pd(L-3)(2)Cl-2, [Pd-2(L-3)(2)Cl-4]center dot H2O, cis-Pd(L-2)(2)Cl-2 and [Pt-3(L-1)(2)Cl-6] were synthesized and characterized by elemental analysis and NMR spectroscopy. The structure of the [Pd-2(L-3)(2)Cl-4]center dot H2O complex was established by Xray crystallography. The two L-3 ligands are found in a head to tail orientation, with a (PdPd)-Pd-... distance of 3.1254(17) angstrom.L-1 coordinates to Pd(II) through N8 and N1 forming polymeric structures. L-2 coordinates to Pd(II) through N8 in acidic solutions (0.1 M HCl) forming complexes of cis-geometry. The Pd(II) coordination to L-2 does not affect the sugar conformation probably due to the high stability of the C-C glycoside bond. (c) 2006 Elsevier B.V. All rights reserved.
Keyword Pd(ii) And Pt(ii) Complexes
C-nucleosides
Triazolopyrimidines
X-ray Crystal Structure
Chemistry, Inorganic & Nuclear
Bridgehead C-nucleosides
Antitumor-activity
Nmr-spectroscopy
Amino-acids
Platinum(ii)
Formycin
Ligands
Q-Index Code C1

 
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Created: Wed, 15 Aug 2007, 19:17:41 EST