Spatial gene expression in the T-stage mouse metanephros

Caruana, Georgina, Cullen-McEwen, Luise, Nelson, Amy L., Kostoulias, Xenia, Woods, Kyra, Gardiner, Brooke, Davis, Melissa J., Taylor, Darrin F., Teasdale, Rohan D., Grimmond, Sean M., Little, Melissa H. and Bertram, John F. (2006) Spatial gene expression in the T-stage mouse metanephros. Gene Expression Patterns, 6 8: 807-825. doi:10.1016/j.modgep.2006.02.001

Author Caruana, Georgina
Cullen-McEwen, Luise
Nelson, Amy L.
Kostoulias, Xenia
Woods, Kyra
Gardiner, Brooke
Davis, Melissa J.
Taylor, Darrin F.
Teasdale, Rohan D.
Grimmond, Sean M.
Little, Melissa H.
Bertram, John F.
Title Spatial gene expression in the T-stage mouse metanephros
Journal name Gene Expression Patterns   Check publisher's open access policy
ISSN 1567-133X
Publication date 2006-01-01
Year available 2006
Sub-type Article (original research)
DOI 10.1016/j.modgep.2006.02.001
Open Access Status Not yet assessed
Volume 6
Issue 8
Start page 807
End page 825
Total pages 19
Editor S. Aizawa
M. Leptin
N. Papalopulu
D. Stainier
C. D. Stern
P. Tam
Place of publication Amsterdam
Publisher Elsevier Science
Language eng
Subject C1
270205 Genetic Development (incl. Sex Determination)
780105 Biological sciences
Abstract The E11.5 mouse metanephros is comprised of a T-stage ureteric epithelial tubule sub-divided into tip and trunk cells surrounded by metanephric mesenchyme (MM). Tip cells are induced to undergo branching morphogenesis by the MM. In contrast, signals within the mesenchyme surrounding the trunk prevent ectopic branching of this region. In order to identify novel genes involved in the molecular regulation of branching morphogenesis we compared the gene expression profiles of isolated tip, trunk and MM cells using Compugen mouse long oligo microarrays. We identified genes enriched in the tip epithelium, sim-1, Arg2, Tacstd1, Crlf-1 and BMP7; genes enriched in the trunk epithelium, Innp1, Itm2b, Mkrn1, SPARC, Emu2 and Gsta3 and genes spatially restricted to the mesenchyme surrounding the trunk, CSPG2 and CV-2, with overlapping and complimentary expression to BMP4, respectively. This study has identified genes spatially expressed in regions of the developing kidney involved in branching morphogenesis, nephrogenesis and the development of the collecting duct system, calyces, renal pelvis and ureter. (c) 2006 Elsevier B.V. All rights reserved.
Keyword metanephros
ureteric epithelium
ureteric tip cells
ureteric trunk cells
metanephric mesenchyme
branching morphogenesis
Receptor Tyrosine Kinase
Kidney Development
Branching Morphogenesis
Ureteral Bud
Restricted Expression
Early Organogenesis
Ret Protooncogene
Renal Development
Collecting Duct
Sonic Hedgehog
Q-Index Code C1
Grant ID DK63400
Institutional Status UQ

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Created: Wed, 15 Aug 2007, 19:14:57 EST