Retinoid signaling determines germ cell fate in mice

Bowles, Josephine, Knight, Deon, Smith, Christopher, Wilhelm, Dagmar, Richman, Joy, Mamiya, Satoru, Yashiro, Kenta, Chawengsaksophak, Kallayanee, Wilson, Megan J., Rossant, Janet, Hamada, Hiroshi and Koopman, Peter (2006) Retinoid signaling determines germ cell fate in mice. Science, 312 5773: 596-600. doi:10.1126/science.1125691


Author Bowles, Josephine
Knight, Deon
Smith, Christopher
Wilhelm, Dagmar
Richman, Joy
Mamiya, Satoru
Yashiro, Kenta
Chawengsaksophak, Kallayanee
Wilson, Megan J.
Rossant, Janet
Hamada, Hiroshi
Koopman, Peter
Title Retinoid signaling determines germ cell fate in mice
Journal name Science   Check publisher's open access policy
ISSN 0036-8075
1095-9203
Publication date 2006-04-28
Sub-type Article (original research)
DOI 10.1126/science.1125691
Open Access Status Not Open Access
Volume 312
Issue 5773
Start page 596
End page 600
Total pages 5
Place of publication Washington, D.C.
Publisher American Association for the Advancement of Science
Language eng
Subject C1
270205 Genetic Development (incl. Sex Determination)
780105 Biological sciences
Abstract Germ cells in the mouse embryo can develop as oocytes or spermatogonia, depending on molecular cues that have not been identified. We found that retinoic acid, produced by mesonephroi of both sexes, causes germ cells in the ovary to enter meiosis and inititate oogenesis. Meiosis is retarded in the fetal testis by the action of the retinoid-degrading enzyme CYP26B1, ultimately leading to spermatogenesis. In testes of Cyp26b1-knockout mouse embryos, germ cells enter meiosis precociously, as if in a normal ovary. Thus, precise regulation of retinoid levels during fetal gonad development provides the molecular control mechanism that specifies germ cell fate.
Keyword Developmental Biology
Mouse
Acid
Fetal
Meiosis
Expression
Testis
Inhibition
Antagonist
Gonocytes
Migration
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2007 Higher Education Research Data Collection
Institute for Molecular Bioscience - Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 480 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 513 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Wed, 15 Aug 2007, 19:11:36 EST