Imaging features of ocular adnexal lymphoproliferative disease

Sullivan, T. J. and Valenzuela, A. A. (2006) Imaging features of ocular adnexal lymphoproliferative disease. Eye, 20 10: 1189-1195. doi:10.1038/sj.eye.6702382

Author Sullivan, T. J.
Valenzuela, A. A.
Title Imaging features of ocular adnexal lymphoproliferative disease
Journal name Eye   Check publisher's open access policy
ISSN 0950-222X
ISBN 978-3-540-85541-5
Publication date 2006-01-01
Year available 2010
Sub-type Article (original research)
DOI 10.1038/sj.eye.6702382
Open Access Status
Volume 20
Issue 10
Start page 1189
End page 1195
Total pages 7
Editor I. Rennie
Place of publication London, U.K.
Publisher Nature Publishing Group
Language eng
Subject C1
11 Medical and Health Sciences
Abstract Purpose To evaluate the imaging characteristics of a cohort of patients with ocular adnexal lymphoproliferative disease (OALD). Methods A noncomparative retrospective review between 1992 and 1995 and prospective study from 1995 to 2005 of the clinical, imaging and treatment of 105 patients presenting to tertiary orbital referral centre presenting with OALD. Results One hundred and five patients (mean age 61 years, range 11-90 years) with equal gender distribution were included. Fifty-three were primary and 52 were secondary. Computed tomography (CT) usually showed a well-circumscribed lesion of greater than brain density, moulding to adjacent tissues with moderate enhancement. Aggressive histology was associated with bone destruction, while moulding was associated with indolent histology (P < 0.005). MRI in OALD showed intermediate signal intensity on T1- and T2-weighted images and moderate enhancement with gadolinium. Gallium scanning sensitivity to detect ocular adnexal disease was 25 and 57% for systemic involvement. Positron emission tomography (PET) upstaged (71%) of patients with systemic lymphoproliferative involvement, having a higher sensitivity than CT in detecting distant disease (86 vs 72%). Conclusions CT and/ or MRI are essential in the evaluation of OALD and can be used to establish that an orbital lesion may be lymphoprolifetaive in nature. Further, these imaging modalities may predict the behaviour of the lymphoma in certain cases. Gallium scanning provides no additional information to CT and does not influence patient treatment. PET represents an important addition to the assessment of OALD with real impact on patient management.
Keyword Lymphoma
Ocular Adnexa
Cooperative Group
Orbital Lymphoma
Final Report
Ga-67 Spect
Q-Index Code C1
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2007 Higher Education Research Data Collection
School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 27 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 31 times in Scopus Article | Citations
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Created: Wed, 15 Aug 2007, 18:58:53 EST