Morbidity due to Schistosoma mansoni: an epidemiological assessment of distended abdomen syndrome in Ugandan school children with observations before and 1-year after anthelminthic chemotherapy

Balen, Julie, Stothard, J. Russell, Kabatereine, Narcis B., Tukahebwa, Edridah M., Kazibwe, Francis, Whawell, Sarah, Webster, Joanne P., Utzinger, Jürg and Fenwick, Alan (2006) Morbidity due to Schistosoma mansoni: an epidemiological assessment of distended abdomen syndrome in Ugandan school children with observations before and 1-year after anthelminthic chemotherapy. Transactions Of The Royal Society Of Tropical Medicine And Hygiene, 100 11: 1039-1048. doi:10.1016/j.trstmh.2005.12.013


Author Balen, Julie
Stothard, J. Russell
Kabatereine, Narcis B.
Tukahebwa, Edridah M.
Kazibwe, Francis
Whawell, Sarah
Webster, Joanne P.
Utzinger, Jürg
Fenwick, Alan
Title Morbidity due to Schistosoma mansoni: an epidemiological assessment of distended abdomen syndrome in Ugandan school children with observations before and 1-year after anthelminthic chemotherapy
Journal name Transactions Of The Royal Society Of Tropical Medicine And Hygiene   Check publisher's open access policy
ISSN 0035-9203
Publication date 2006-11-01
Sub-type Article (original research)
DOI 10.1016/j.trstmh.2005.12.013
Volume 100
Issue 11
Start page 1039
End page 1048
Total pages 10
Place of publication London, England
Publisher Elsevier
Language eng
Subject CX
1117 Public Health and Health Services
Abstract The objectives of this study were to determine the prevalence and distribution of distended abdomens among Ugandan school children across a range of eco-epidemiological settings and to investigate the relationship between distended abdomens and helminth infections, in particular Schistosoma mansoni, before and 1-year after anthelminthic treatment. A cross-sectional survey was conducted on 4354 school children across eight districts, with a longitudinal 1-year follow-up of 2644 children (60.7%). On both occasions, parasitological, biometrical and clinical data were collected for each child. Baseline prevalence of S. mansoni and hookworms was 44.3% and 51.8%, respectively. Distended abdomens, defined as an abdominal circumference ratio (ACR) >1.05, were observed in 2.5% of the sampled children, several of whom presented with particularly severe distensions necessitating hospital referral. ACR scores were highly overdispersed between districts and schools. Multivariate regression analysis revealed that S. mansoni infection accounted for only a small fraction of ACR variation, suggesting that either single point prevalence and intensity measures failed to reflect this more chronically evolved morbidity and/or that other interacting factors were involved, e.g. malnutrition and malaria. At 1-year follow-up, ACR scores showed an overall trend of regression towards the mean, potentially indicative of amelioration following chemotherapy, but geographic overdispersion still remained. © 2006 Royal Society of Tropical Medicine and Hygiene.
Keyword intestinal schistosomiasis
Schistosoma mansoni
morbidity
hepatosplenomegaly
ascites
deworming
Uganda
Q-Index Code CX

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Public Health Publications
 
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Created: Wed, 15 Aug 2007, 18:56:50 EST