Familial aggregation of human infection with Schistosoma japonicum in the Poyang Lake region, China

Ellis, M. K., Li, Y. S., Rong, Z., Chen, H. G. and McManus, D. P. (2006) Familial aggregation of human infection with Schistosoma japonicum in the Poyang Lake region, China. International Journal For Parasitology, 36 1: 71-77. doi:10.1016/j.ijpara.2005.09.006


Author Ellis, M. K.
Li, Y. S.
Rong, Z.
Chen, H. G.
McManus, D. P.
Title Familial aggregation of human infection with Schistosoma japonicum in the Poyang Lake region, China
Journal name International Journal For Parasitology   Check publisher's open access policy
ISSN 0020-7519
Publication date 2006-01-01
Sub-type Article (original research)
DOI 10.1016/j.ijpara.2005.09.006
Open Access Status Not yet assessed
Volume 36
Issue 1
Start page 71
End page 77
Total pages 7
Place of publication Oxford
Publisher Pergamon-Elsevier Science Ltd
Language eng
Subject C1
Abstract Despite the success of extensive control measures that have been implemented in China for over 50 years, the number of individuals infected with Schistosoma japonicum remains high in the existing endemic areas. A variance components analysis was undertaken to estimate the heritable and environmental components that contribute to S. japonicum infection in the Poyang Lake region of Jiangxi Province, PR China. The total target population was 3148 from four separate administrative villages. Two thousand seven hundred and five of these comprised 400 families ranging in size from 3 to 188. After adjustments were made for gender, water contact and past history of having had schistosomiasis, the heritable component was estimated to account for as much as 58% of the phenotype variation under the polygenic model. Household was not shown to be an important environmental factor. Incorporating village effects indicated that the results were valid for the total population. We conclude that genetic heritability in this region is high and plays an important role in determining risk of infection with S. japonicum. (c) 2005 Australian Society for Parasitology Inc. Published by Elsevier Ltd. All rights reserved.
Keyword Schistosomiasis
Genetic Epidemiology
Variance Components
Schistosoma Japonicum
China
Parasitology
Western Cote-divoire
Fecal Egg Excretion
Chromosome 5q31-q33
Mansoni Infection
Major Gene
Resistance
Intensity
Locus
Susceptibility
Reinfection
Q-Index Code C1
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
2007 Higher Education Research Data Collection
School of Medicine Publications
 
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Created: Wed, 15 Aug 2007, 18:45:24 EST