Mechanisms of the effect of magnesium salts in preeclampsia

Chiarello, Delia I, Marín, Reinaldo, Proverbio, Fulgencio, Coronado, Paula, Toledo, Fernando, Salsoso, Rocio, Gutiérrez, Jaime and Sobrevia, Luis (2018) Mechanisms of the effect of magnesium salts in preeclampsia. Placenta, . doi:10.1016/j.placenta.2018.04.011


Author Chiarello, Delia I
Marín, Reinaldo
Proverbio, Fulgencio
Coronado, Paula
Toledo, Fernando
Salsoso, Rocio
Gutiérrez, Jaime
Sobrevia, Luis
Title Mechanisms of the effect of magnesium salts in preeclampsia
Journal name Placenta   Check publisher's open access policy
ISSN 1532-3102
Publication date 2018-04-24
Sub-type Article (original research)
DOI 10.1016/j.placenta.2018.04.011
Open Access Status Not yet assessed
Abstract Preeclampsia is a heterogeneous pregnancy-specific syndrome associated with abnormal trophoblast invasion and endothelial dysfunction. Magnesium (Mg) level may be normal or decreased in women with preeclampsia. However, the use of Mg salts, such as Mg sulphate, are useful in reducing the pathophysiological consequences of preeclampsia with severe features and eclampsia. Although the mechanism of action of this Mg salt is not well understood, the available evidence suggests a beneficial effect of Mg for the mother and foetus. The mechanisms include a lower level of soluble fms-like tyrosine kinase 1 and endoglin, blockage of brain N-methyl-D-aspartate receptors, decreased inflammation mediators, activation of nitric oxide synthases, blockage of arginases, and reduced free radicals level. The maintenance of Mg homeostasis in pregnancy is crucial for an appropriate pregnancy progression. Oral Mg salts can be used for this purpose which could result in mitigating the deleterious consequences of this syndrome to the mother, foetus, and newborn.
Keyword Eclampsia
Human
Magnesium
Magnesium salts
Placenta
Preeclampsia
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Pubmed Import
 
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Created: Wed, 09 May 2018, 10:09:57 EST