Effect of drug concentration on adsorption of levofloxacin by polyacrylonitrile haemofilters

Tian, Qi, Gomersall, Charles D., Wong, April, Leung, Patricia, Choi, Gordon, Joynt, Gavin M., Tan, Perpetua and Lipman, Jeff (2006) Effect of drug concentration on adsorption of levofloxacin by polyacrylonitrile haemofilters. International Journal of Antimicrobial Agents, 28 2: 147-150. doi:10.1016/j.ijantimicag.2006.03.025

Author Tian, Qi
Gomersall, Charles D.
Wong, April
Leung, Patricia
Choi, Gordon
Joynt, Gavin M.
Tan, Perpetua
Lipman, Jeff
Title Effect of drug concentration on adsorption of levofloxacin by polyacrylonitrile haemofilters
Journal name International Journal of Antimicrobial Agents   Check publisher's open access policy
ISSN 0924-8579
Publication date 2006-01-01
Year available 2006
Sub-type Article (original research)
DOI 10.1016/j.ijantimicag.2006.03.025
Open Access Status
Volume 28
Issue 2
Start page 147
End page 150
Total pages 4
Editor A. M. Geddes
Place of publication Amsterdam, Netherlands
Publisher Elsevier Science Bv
Language eng
Subject C1
321009 Intensive Care
730199 Clinical health not specific to particular organs, diseases and conditions
11 Medical and Health Sciences
1115 Pharmacology and Pharmaceutical Sciences
Abstract We studied an in vitro model of continuous venovenous haemofiltration to determine levofloxacin adsorption by polyacrylonitrile (PAN) filters. Four doses of levofloxacin (5, 25, 50 and 100 mg) were used, resulting in circulating concentrations of levofloxacin at 120 min of 3.56 +/- 0.14, 15.84 +/- 2.08, 31.42 +/- 1.95 and 58.23 +/- 1.10 mg/L, respectively. Adsorption at 2 h was 0.65 +/- 0.17, 5.99 +/- 2.49, 12.30 +/- 2.34 and 30.13 +/- 1.32 mg, respectively (P < 0.001). From 2 h to 4 h, increasing the blood pump rate and the ultrafiltration rate had no effect on adsorption. When the concentration was decreased from 3.55 +/- 0.13 mg/L at 4 h to 2.16 +/- 0.11 mg/L at 5 h by addition of lactated Ringer's solution, adsorption decreased from 0.67 +/- 0.16 mg to 0.21 +/- 0.25 mg (P < 0.05). These data show that adsorption of levofloxacin by PAN haemofilters is concentration dependent and reversible in vitro and suggest that adsorption by haemofilters is unlikely to affect levofloxacin pharmacokinetics significantly in vivo. (c) 2006 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.
Keyword Renal Replacement Therapy
Kidney Failure
Infectious Diseases
Pharmacology & Pharmacy
Continuous Venovenous Hemofiltration
Critically Ill Patients/
Q-Index Code C1
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
2007 Higher Education Research Data Collection
School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 19 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 20 times in Scopus Article | Citations
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Created: Wed, 15 Aug 2007, 18:40:38 EST