Does the p75 neurotrophin receptor mediate A beta-induced toxicity in Alzheimer's disease?

Coulson, Elizabeth J. (2006) Does the p75 neurotrophin receptor mediate A beta-induced toxicity in Alzheimer's disease?. Journal of Neurochemistry, 98 3: 654-660. doi:10.1111/j.1471-4159.2006.03905.x


Author Coulson, Elizabeth J.
Title Does the p75 neurotrophin receptor mediate A beta-induced toxicity in Alzheimer's disease?
Journal name Journal of Neurochemistry   Check publisher's open access policy
ISSN 0022-3042
1471-4159
Publication date 2006-01-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1111/j.1471-4159.2006.03905.x
Volume 98
Issue 3
Start page 654
End page 660
Total pages 7
Editor A. J. Turner
B. Collier
Place of publication Oxford, UK
Publisher Blackwell Publishing
Language eng
Subject C1
320702 Central Nervous System
730104 Nervous system and disorders
1109 Neurosciences
Abstract Alzheimer's disease is characterized by the over-production and accumulation of amyloidogenic A beta peptide, which can induce cell death in vitro. It has been suggested that the death signal could be transduced by the pan neurotrophin receptor (p75NTR). p75NTR is well known for its ability to mediate neuronal death in neurodegenerative conditions and is inextricably linked with changes that occur in Alzheimer's disease. Moreover, A beta binds to p75NTR, activating signalling cascades. However, the complexity of p75NTR-mediated signalling, which does not always promote cell death, leaves open the possibly of A beta promoting death via an alternative signalling pathway or the regulation of other p75NTR-mediated actions. This review focuses on the interactions between A beta and p75NTR in the context of the broader p75NTR signalling field, and offers alternative explanations for how p75NTR might contribute to the aetiology of Alzheimer's disease.
Keyword Amyloid
Apoptosis
C-jun Kinase
Nuclear Factor Kappa B
P75 Nerve Growth Factor Receptor
Biochemistry & Molecular Biology
Neurosciences
Nerve Growth-factor
Neuronal Cell-death
Nf-kappa-b
Regulated Intramembrane Proteolysis
Mild Cognitive Impairment
Long-term Depression
Amyloid Peptide
Neurite Outgrowth
Trka Receptor
Stem-cells
Q-Index Code C1
Additional Notes This document is a journal review.

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Excellence in Research Australia (ERA) - Collection
2007 Higher Education Research Data Collection
Queensland Brain Institute Publications
 
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Created: Wed, 15 Aug 2007, 18:39:05 EST