Carriage of methicillin-resistant Staphylococcus aureus in a Queensland Indigenous community

Vlack, S. A., Cox, L., Peleg, A., Canuto, C. G., Stewart, C., Conlon, A., Giffard, P. M., Huygens, F., Mollinger, A., Vohra, R., McCarthy, J. S. and Stephens, A. (2006) Carriage of methicillin-resistant Staphylococcus aureus in a Queensland Indigenous community. Medical Journal Of Australia, 184 11: 556-559.

Author Vlack, S. A.
Cox, L.
Peleg, A.
Canuto, C. G.
Stewart, C.
Conlon, A.
Giffard, P. M.
Huygens, F.
Mollinger, A.
Vohra, R.
McCarthy, J. S.
Stephens, A.
Title Carriage of methicillin-resistant Staphylococcus aureus in a Queensland Indigenous community
Journal name Medical Journal Of Australia   Check publisher's open access policy
ISSN 0025-729X
Publication date 2006-06-05
Sub-type Article (original research)
Volume 184
Issue 11
Start page 556
End page 559
Total pages 4
Editor M. Van Der Weyden
Place of publication Strawberry Hills, NSW, Australia
Publisher Australasian Medical Publishing
Language eng
Subject C1
321207 Indigenous Health
730206 Aboriginal and Torres Strait Islander health
Formatted abstract
Objective: To determine the prevalence of community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) carriage and infection among children living in an Indigenous community in Queensland.
Design, setting and participants: Swabs for culture of S. aureus were collected from the nose, throat and skin wounds of primary school children.
Main outcome measures: MRSA carriage, antibiotic sensitivity, genotype, and presence of the virulence factor Panton-Valentine leukocidin (PVL); and epidemiological risk factors for MRSA carriage.
Results: 92 (59%) of 157 eligible children were included in the study. Twenty-seven (29%) carried S. aureus; 14 of these (15% of total) carried MRSA. MRSA was isolated from 29% of wound swabs, 8% of nose swabs, and 1 % of throat swabs. Fourteen of 15 M RSA isolates were sensitive to all non-beta-lactam antibiotics tested. Eight children (9%) carried CA-MRSA clonal types: six carried the Queensland clone (ST93), and two carried the South West Pacific clone (ST30). All these isolates carried the virulence factor PVL. The remaining six children carried a hospital-associated MRSA strain (ST5), negative for PVL.
Conclusions: We have identified a high prevalence of CA-MRSA carriage in school children from a Queensland Indigenous community. In this setting, antibiotics with activity against CA-MRSA should be considered for empiric therapy of suspected staphylococcal infection. Larger community-based studies are needed to improve our understanding of the epidemiology of CA-MRSA, and to assist in the development of therapeutic guidelines for this important infection.
Keyword Medicine, General and Internal
Western Australia
Healthy children
Nasal Carriage
Q-Index Code C1
Additional Notes Impact Factor = 2.127. This article published in the Medical Journal of Australia presented community level epidemiological information about schoolchildren not previously documented in Australia in regard to an emerging infection. The study involved a community collaboration process in relation to a research issue requiring rapid action also previously not well documented in a mainstream journal in Australia.

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Created: Wed, 15 Aug 2007, 18:29:31 EST