A systematic review and meta-analysis of the diagnostic accuracy of rapid immunochromatographic assays for the detection of dengue virus IgM antibodies during acute infection

Blacksell, S. D. (2006) A systematic review and meta-analysis of the diagnostic accuracy of rapid immunochromatographic assays for the detection of dengue virus IgM antibodies during acute infection. Transactions of The Royal Society of Tropical Medicine And Hygiene, 100 8: 775-784. doi:10.1016/j.trstmh.2005.10.018


Author Blacksell, S. D.
Title A systematic review and meta-analysis of the diagnostic accuracy of rapid immunochromatographic assays for the detection of dengue virus IgM antibodies during acute infection
Journal name Transactions of The Royal Society of Tropical Medicine And Hygiene   Check publisher's open access policy
ISSN 0035-9203
Publication date 2006-01-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.trstmh.2005.10.018
Volume 100
Issue 8
Start page 775
End page 784
Total pages 10
Place of publication London
Publisher Royal Soc Tropical Medicine
Language eng
Subject CX
C1
321010 Infectious Diseases
730101 Infectious diseases
Abstract A meta-analysis of rapid (<= 60 min) dengue diagnostic assays was conducted to determine accuracy and identify causes of between-study heterogeneity. A systematic review identified 302 potentially suitable studies, of which 11 were selected for meta-analysis. All selected studies evaluated the immunochromatographic test (ICT) manufactured by Panbio Pty Ltd. Individual study results for sensitivity ranged from 0.45 to 1.0, specificity 0.57-1.0, diagnostic odds ratio 4.5-1287, and positive: negative likelihood ratios 2.3-59 and 0.01-0.56, respectively. Results indicated that the ICT evaluated in the selected studies can both rule in and rule out disease but is more accurate when samples are collected Later in the acute phase of infection. Limitations of this meta-analysis were significant between-study heterogeneity caused by inconsistencies in evaluation methodologies, and the evaluation of only the Panbio ICT. It is recommended that additional., standardized evaluations are required for other dengue ICTS. (C) 2005 Royal Society of Tropical Medicine and Hygiene. Published by Elsevier Ltd. All rights reserved.
Keyword dengue
diagnosis
immunochromatographic test
IgM
antibody
Public, Environmental & Occupational Health
Q-Index Code C1
Additional Notes This document is a journal review.

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Excellence in Research Australia (ERA) - Collection
School of Medicine Publications
 
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Created: Wed, 15 Aug 2007, 18:19:15 EST