A possible smoking susceptibility locus on chromosome 11p12: Evidence from sex-limitation linkage analyses in a sample of Australian twin families

Morley, Katherine I., Medland, Sarah E., Ferreira, Manuel A. R., Lynskey, Michael T., Montgomery, Grant W., Heath, Andrew C., Madden, Pamela A. F. and Martin, Nicholas G. (2006) A possible smoking susceptibility locus on chromosome 11p12: Evidence from sex-limitation linkage analyses in a sample of Australian twin families. Behavior Genetics, 36 1: 87-99. doi:10.1007/s10519-005-9004-0


Author Morley, Katherine I.
Medland, Sarah E.
Ferreira, Manuel A. R.
Lynskey, Michael T.
Montgomery, Grant W.
Heath, Andrew C.
Madden, Pamela A. F.
Martin, Nicholas G.
Title A possible smoking susceptibility locus on chromosome 11p12: Evidence from sex-limitation linkage analyses in a sample of Australian twin families
Journal name Behavior Genetics   Check publisher's open access policy
ISSN 0001-8244
1573-3297
Publication date 2006-01-01
Sub-type Article (original research)
DOI 10.1007/s10519-005-9004-0
Volume 36
Issue 1
Start page 87
End page 99
Total pages 13
Editor J. K. Hewitt
Place of publication New York, United States
Publisher Springer
Language eng
Subject 321011 Medical Genetics
730107 Inherited diseases (incl. gene therapy)
Abstract Many twin studies have identified sex differences in the influence of genetic and environmental factors on smoking behaviors. We explore the evidence for sex differences for smoking initiation and cigarette consumption in a sample of Australian twin families, and extend these models to incorporate sex differences in linkage analyses for these traits. We further examine the impact of including or excluding non-smokers in genetic analyses of tobacco consumption. Accounting for sex differences improved linkage results in some instances. We identified one region suggestive of linkage on chromosome 11p12. This locus, as well as another region identified on chromosome 6p12, replicates regions identified in previous studies.
Keyword Behavioral sciences
Genetics & heredity
Psychology, multidisciplinary
Linkage
Sex differences
Smoking
Twin Study
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: ERA 2012 Admin Only
School of Psychology Publications
Institute for Molecular Bioscience - Publications
 
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Created: Wed, 15 Aug 2007, 18:17:29 EST