Over-expression of Eph and ephrin genes in advanced ovarian cancer: ephrin gene expression correlates with shortened survival

Herath, Nirmitha I., Spanevello, Mark D., Sabesan, Sabe, Newton, Tanya, Cummings, Margaret, Duffy, Shannon, Lincoln, Douglas, Boyle, Glen, Parsons, Peter G. and Boyd, Andrew W. (2006) Over-expression of Eph and ephrin genes in advanced ovarian cancer: ephrin gene expression correlates with shortened survival. BMC Cancer, 6 144: . doi:10.1186/1471-2407-6-144


Author Herath, Nirmitha I.
Spanevello, Mark D.
Sabesan, Sabe
Newton, Tanya
Cummings, Margaret
Duffy, Shannon
Lincoln, Douglas
Boyle, Glen
Parsons, Peter G.
Boyd, Andrew W.
Title Over-expression of Eph and ephrin genes in advanced ovarian cancer: ephrin gene expression correlates with shortened survival
Journal name BMC Cancer   Check publisher's open access policy
ISSN 1471-2407
Publication date 2006-06-01
Sub-type Article (original research)
DOI 10.1186/1471-2407-6-144
Open Access Status DOI
Volume 6
Issue 144
Total pages 7
Editor F. Godlee
P. Newmark
Place of publication London, U.K.
Publisher BioMed Central
Language eng
Subject C1
321014 Obstetrics and Gynaecology
730116 Reproductive system and disorders
Abstract Background: Increased expression of Eph receptor tyrosine kinases and their ephrin ligands has been implicated in tumor progression in a number of malignancies. This report describes aberrant expression of these genes in ovarian cancer, the commonest cause of death amongst gynaecological malignancies. Methods: Eph and ephrin expression was determined using quantitative real time RT-PCR. Correlation of gene expression was measured using Spearman's rho statistic. Survival was analysed using log-rank analysis and ( was visualised by) Kaplan-Meier survival curves. Results: Greater than 10 fold over-expression of EphA1 and a more modest over-expression of EphA2 were observed in partially overlapping subsets of tumors. Over-expression of EphA1 strongly correlated ( r = 0.801; p < 0.01) with the high affinity ligand ephrin A1. A similar trend was observed between EphA2 and ephrin A1 ( r = 0.387; p = 0.06). A striking correlation of both ephrin A1 and ephrin A5 expression with poor survival ( r = - 0.470; p = 0.02 and r = - 0.562; p < 0.01) was observed. Intriguingly, there was no correlation between survival and other clinical parameters or Eph expression. Conclusion: These data imply that increased levels of ephrins A1 and A5 in the presence of high expression of Ephs A1 and A2 lead to a more aggressive tumor phenotype. The known functions of Eph/ephrin signalling in cell de-adhesion and movement may explain the observed correlation of ephrin expression with poor prognosis.
Keyword Oncology
Receptor Tyrosine Kinase
Intestinal Epithelium
Melanoma Progression
Growth-factor
Carcinoma
Carcinogenesis
Tumorigenesis
Embryogenesis
Ligands
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
2007 Higher Education Research Data Collection
School of Medicine Publications
 
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Created: Wed, 15 Aug 2007, 18:07:41 EST