Developmental vitamin D (DVD) deficiency in the rat alters adult behaviour independently of HPA function

Eyles, D. W., Rogers, F., Buller, K., McGrath, J. J., Ko, P., French, K. and Burne, T. H. J. (2006) Developmental vitamin D (DVD) deficiency in the rat alters adult behaviour independently of HPA function. Psychoneuroendocrinology, 31 8: 958-964. doi:10.1016/j.psyneuen.2006.05.006


Author Eyles, D. W.
Rogers, F.
Buller, K.
McGrath, J. J.
Ko, P.
French, K.
Burne, T. H. J.
Title Developmental vitamin D (DVD) deficiency in the rat alters adult behaviour independently of HPA function
Journal name Psychoneuroendocrinology   Check publisher's open access policy
ISSN 0306-4530
Publication date 2006-01-01
Sub-type Article (original research)
DOI 10.1016/j.psyneuen.2006.05.006
Volume 31
Issue 8
Start page 958
End page 964
Total pages 7
Editor Ned H. Kalin
Robert Dantzer
Place of publication United Kingdom
Publisher Pergamon
Collection year 2006
Language eng
Subject C1
Abstract Developmental vitamin D deficiency (DVD) has been shown to alter the orderly pattern of brain development. Even though the period of vitamin D deficiency is restricted to gestation this is sufficient to induce behavioural abnormalities in the adult offspring consistent with those seen in many animal models of schizophrenia. Given that some of these behavioural alterations could also be an indirect result of either impaired maternal hypothalamic pituitary axis (HPA) function (which in turn could influence maternal care) or the result of a permanent alteration in HPA function in the adult offspring we have examined HPA status in both maternal animals and adult offspring. In this study we have established that HPA function is normal in the maternally vitamin D deficient rat. We replicate the behavioural phenotype of hyperlocomotion whilst establishing that HPA function is also unchanged in the adult mate offspring. We conclude that the behavioural alterations induced by DVD deficiency are due to some adverse event in brain development rather than via an alteration in stress response. (c) 2006 Elsevier Ltd. All rights reserved.
Keyword Endocrinology & Metabolism
Neurosciences
Spontaneous Locomotion
Vitamin D
Brain Development
Behaviour
Hpa Axis
Nerve Growth-factor
Brain-development
D-receptor
1,25-dihydroxyvitamin-d3
Schizophrenia
Expression
Hypothesis
Mothers
Stress
Cells
Q-Index Code C1

 
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Created: Wed, 15 Aug 2007, 17:59:44 EST