Myoepithelial calls: Pathology, cell separation and markers of myoepithelial differentiation

Clarke, Catherine, Sandle, Jennifer and Lakhani, Sunil R. (2005) Myoepithelial calls: Pathology, cell separation and markers of myoepithelial differentiation. Journal of Mammary Gland Biology and Neoplasia, 10 3: 273-280. doi:10.1007/s10911-005-9587-3

Author Clarke, Catherine
Sandle, Jennifer
Lakhani, Sunil R.
Title Myoepithelial calls: Pathology, cell separation and markers of myoepithelial differentiation
Journal name Journal of Mammary Gland Biology and Neoplasia   Check publisher's open access policy
ISSN 1083-3021
Publication date 2005-07-01
Sub-type Article (original research)
DOI 10.1007/s10911-005-9587-3
Open Access Status Not yet assessed
Volume 10
Issue 3
Start page 273
End page 280
Total pages 8
Editor G. C. Chamness
K. L. Carraway
Place of publication New York, U.S.A.
Publisher Springer New York LLC
Language eng
Subject C1
321020 Pathology
730108 Cancer and related disorders
Abstract Until recently the myoepithelial cell has been studied relatively little in terms of its role in breast cancer. A number of malignancies showing myoepithelial differentiation have been reported in the literature, although they are still thought to be relatively rare and only limited studies are published. As a result of recent expression profiling experiments, one type of tumor with myoepithelial features, the so-called 'basal' breast cancer, has received a renewed interest, although it has been known to pathologists for more than two decades. These tumors, which express markers of both luminal and myoepithelial cells, are now being studied using antibodies against some new molecules that have emerged from studies of sorted normal luminal and myoepithelial cells. These immunohistochemical data, combined with genomic studies, may lead to better identification and management of patients with 'basal' tumors.
Keyword Endocrinology and Metabolism
cell separation
myoepithelial tumors
basal-like tumors
basal markers
Q-Index Code C1
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
2007 Higher Education Research Data Collection
School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 15 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 17 times in Scopus Article | Citations
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Created: Wed, 15 Aug 2007, 17:55:55 EST