Connective tissue panniculitis in a child with vitiligo and Hashimoto's thyroiditis

Mirza, B., Muir, J. and Peake, J. (2006) Connective tissue panniculitis in a child with vitiligo and Hashimoto's thyroiditis. Australasian Journal of Dermatology, 47 1: 49-52. doi:10.1111/j.1440-0960.2006.00223.x

Author Mirza, B.
Muir, J.
Peake, J.
Title Connective tissue panniculitis in a child with vitiligo and Hashimoto's thyroiditis
Journal name Australasian Journal of Dermatology   Check publisher's open access policy
ISSN 0004-8380
Publication date 2006-01-01
Sub-type Article (original research)
DOI 10.1111/j.1440-0960.2006.00223.x
Open Access Status Not Open Access
Volume 47
Issue 1
Start page 49
End page 52
Total pages 4
Editor D. Dyall-Smith
Place of publication Carlton South, Australia
Publisher Blackwell Publishing Asia
Language eng
Subject C1
320207 Autoimmunity
730102 Immune system and allergy
321002 Dermatology
321004 Endocrinology
730117 Skin and related disorders
730105 Endocrine organs and diseases (incl. diabetes)
Abstract A 9-year-old girl presented with a 6-month history of inflamed tender nodules in the pretibial area. These eventually healed leaving depressed areas of atrophy and loss of subcutaneous tissue. Histology showed a predominantly lymphocytic lobular panniculitis, consistent with connective tissue panniculitis. Investigations revealed an elevated thyroid stimulating hormone, elevated thyroid antiperoxidase antibody and a weakly positive antinuclear antibody (titre 1 in 40). She was commenced on hydroxychloroquine 300 mg daily, which resulted in resolution of the pannictulitis. She developed focal Vitiligo oil the thighs. This gradually improved with 0.1% mometasone furoate ointment. The hydroxychloroquine dose was tapered to 200 mg daily after 12 months, then to 100 mg daily after 18 months therapy. Her thyroid autoantibody levels continued to rise and the hydroxychloroquine was increased again to 300 mg daily. She became borderline hyothyroid. Hashimoto's thyroiditis was diagnosed. Thyroxine was instituted with a resultant improvement in her thyroid blood tests. The lipoatrophy has not developed further during 2-year follow up.
Keyword Dermatology
Antinuclear Antibody
Lipoatrophic Panniculitis
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2007 Higher Education Research Data Collection
School of Medicine Publications
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Created: Wed, 15 Aug 2007, 17:55:42 EST