Towards the preparative and large-scale precision manafacture of virus-like particles

Pattenden, L. K., Middelberg, A. P. J., Niebert, M. and Lipin, D. I. (2005) Towards the preparative and large-scale precision manafacture of virus-like particles. Trends in Biotechnology, 23 10: 523-529. doi:10.1016/j.tibtech.2005.07.011


Author Pattenden, L. K.
Middelberg, A. P. J.
Niebert, M.
Lipin, D. I.
Title Towards the preparative and large-scale precision manafacture of virus-like particles
Journal name Trends in Biotechnology   Check publisher's open access policy
ISSN 0167-7799
Publication date 2005-01-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.tibtech.2005.07.011
Volume 23
Issue 10
Start page 523
End page 529
Total pages 7
Editor A Hinde
S Berry
Place of publication London
Publisher Elsevier Science London
Language eng
Subject C1
290699 Chemical Engineering not elsewhere classified
670499 Other
670799 Other
670199 Processed food products and beverages not elsewhere classified
Abstract Virus-like particles (VLPs) are of interest in vaccination, gene therapy and drug delivery, but their potential has yet to be fully realized. This is because existing laboratory processes, when scaled, do not easily give a compositionally and architecturally consistent product. Research suggests that new process routes might ultimately be based on chemical processing by self-assembly, involving the precision manufacture of precursor capsomeres followed by in vitro VLP self-assembly and scale-up to required levels. A synergistic interaction of biomolecular design and bioprocess engineering (i.e. biomolecular engineering) is required if these alternative process routes and, thus, the promise of new VLP products, are to be realized.
Keyword Biotechnology & Applied Microbiology
Major Capsid Protein
Cellular Immune-responses
Viral Coat Protein
In-vitro
Escherichia-coli
Baculovirus System
Light-scattering
Polyomavirus-jc
Vaccinia Virus
Gene-transfer
Q-Index Code C1

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Excellence in Research Australia (ERA) - Collection
School of Chemical Engineering Publications
2006 Higher Education Research Data Collection
 
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Created: Wed, 15 Aug 2007, 17:53:31 EST