Antibiotic resistance in the intensive care unit: A primer in bacteriology

Iredell, J. and Lipman, J. (2005) Antibiotic resistance in the intensive care unit: A primer in bacteriology. Anaesthesia and Intensive Care, 33 2: 188-195.

Author Iredell, J.
Lipman, J.
Title Antibiotic resistance in the intensive care unit: A primer in bacteriology
Journal name Anaesthesia and Intensive Care   Check publisher's open access policy
ISSN 0310-057X
Publication date 2005-01-01
Sub-type Article (original research)
Open Access Status Not Open Access
Volume 33
Issue 2
Start page 188
End page 195
Total pages 8
Editor A. W. Duncan
Place of publication Edgecliff, Australia
Publisher Australian Soc Anaesthetists
Language eng
Subject 11 Medical and Health Sciences
1103 Clinical Sciences
Abstract The clinical use of potent, well-tolerated, broad-spectrum antibiotics has been paralleled by the development of resistance in bacteria, and the prevalence of highly resistant bacteria in some intensive care units is despairingly commonplace. The intensive care community faces the realistic prospect of untreatable nosocomial infections and should be searching for new approaches to diagnose and manage resistant bacteria. In this review, we discuss some of the relevant underlying biology, with a particular focus on genetic transfer vehicles and the relationship of selection pressure to their movements. It is an attempt to demystify the relevant language and concepts for the anaesthetist and intensivist, to explain some of the reasons for the emergence of resistance in bacteria, and to provide a contextual basis for discussion of management approaches such as selective decontamination and antibiotic cycling.
Keyword Pneumonia : Prediction
Critical Care Medicine
Antibiotic, Resistance, Intensive Care
Ventilator-associated Pneumonia
Blood-stream Infections
Mobile Gene Cassettes
Selective Decontamination
Antimicrobial Resistance
Pathogenicity Island
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
2006 Higher Education Research Data Collection
School of Medicine Publications
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Created: Wed, 15 Aug 2007, 17:23:18 EST