Pathways to improving skin regeneration

Adolphe, C. M. and Wainwright, B. J. (2005) Pathways to improving skin regeneration. Expert Reviews in Molecular Medicine, 7 20: 1-14. doi:10.1017/S1462399405009890

Author Adolphe, C. M.
Wainwright, B. J.
Title Pathways to improving skin regeneration
Journal name Expert Reviews in Molecular Medicine   Check publisher's open access policy
ISSN 1462-3994
Publication date 2005-09-01
Sub-type Article (original research)
DOI 10.1017/S1462399405009890
Volume 7
Issue 20
Start page 1
End page 14
Total pages 14
Place of publication Cambridge, UK
Publisher Cambridge University Press
Language eng
Subject C1
270299 Genetics not elsewhere classified
780105 Biological sciences
Abstract A significant proportion of the human population suffers from some form of skin disorder, whether it be from burn injury or inherited skin anomalies. The ideal treatment for skin disorders would be to regrow skin tissue from stem cells residing in the individual patient's skin. Locating these adult stem cells and elucidating the molecules involved in orchestrating the production of new skin cells are important steps in devising more-efficient methods of skin production and wound healing via the ex vivo expansion of patient keratinocytes in culture. This review focuses on the structure of the skin, the identification of skin stem cells, and the role of Notch, Wnt and Hedgehog signalling cascades in regulating the fate of epidermal stem cells. © 2005 Cambridge University Press.
Q-Index Code C1

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Created: Wed, 15 Aug 2007, 17:15:22 EST