SK channels regulate excitatory synaptic transmission and plasticity in the lateral amygdala

Faber, E. S., Delaney, A. J. and Sah, P. (2005) SK channels regulate excitatory synaptic transmission and plasticity in the lateral amygdala. Nature Neuroscience, 8 5: 635-641. doi:10.1038/nn1450


Author Faber, E. S.
Delaney, A. J.
Sah, P.
Title SK channels regulate excitatory synaptic transmission and plasticity in the lateral amygdala
Journal name Nature Neuroscience   Check publisher's open access policy
ISSN 1097-6256
Publication date 2005-01-01
Sub-type Article (original research)
DOI 10.1038/nn1450
Volume 8
Issue 5
Start page 635
End page 641
Total pages 7
Editor Sandra Aamadt
Place of publication New York
Publisher Nature Publishing Group
Collection year 2005
Language eng
Subject C1
320702 Central Nervous System
730104 Nervous system and disorders
Abstract At glutamatergic synapses, calcium influx through NMDA receptors (NMDARs) is required for long-term potentiation (LTP); this is a proposed cellular mechanism underlying memory and learning. Here we show that in lateral amygdala pyramidal neurons, SK channels are also activated by calcium influx through synaptically activated NMDARs, resulting in depression of the synaptic potential. Thus, blockade of SK channels by apamin potentiates fast glutamatergic synaptic potentials. This potentiation is blocked by the NMDAR antagonist AP5 (D(-)-2-amino-5-phosphono-valeric acid) or by buffering cytosolic calcium with BAPTA. Blockade of SK channels greatly enhances LTP of cortical inputs to lateral amygdala pyramidal neurons. These results show that NMDARs and SK channels are colocalized at glutamatergic synapses in the lateral amygdala. Calcium influx through NMDARs activates SK channels and shunts the resultant excitatory postsynaptic potential. These results demonstrate a new role for SK channels as postsynaptic regulators of synaptic efficacy.
Keyword Ca2+-activated K+ Channels
Hippocampal Pyramidal Neurons
Long-term Potentiation
Activated Potassium Currents
Nmda-receptor Activation
Dendritic Spines
Lesioned Mice
Hair-cells
In-vitro
Calcium
Neurosciences
Q-Index Code C1

 
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Created: Wed, 15 Aug 2007, 17:04:56 EST