Novel markers for poor prognosis in head and neck cancer

Chin, D., Boyle, G. M., Williams, R. M., Ferguson, K., Pandeya, N., Pedley, J., Campbell, C. M., Theile, D. R., Parsons, P. G. and Coman, W. B. (2005) Novel markers for poor prognosis in head and neck cancer. International Journal of Cancer, 113 5: 789-797. doi:10.1002/ijc.20608


Author Chin, D.
Boyle, G. M.
Williams, R. M.
Ferguson, K.
Pandeya, N.
Pedley, J.
Campbell, C. M.
Theile, D. R.
Parsons, P. G.
Coman, W. B.
Title Novel markers for poor prognosis in head and neck cancer
Journal name International Journal of Cancer   Check publisher's open access policy
ISSN 0020-7136
Publication date 2005-01-01
Sub-type Article (original research)
DOI 10.1002/ijc.20608
Volume 113
Issue 5
Start page 789
End page 797
Total pages 9
Editor H. zur Hausen
Place of publication USA
Publisher John Wiley & Sons Inc
Collection year 2005
Language eng
Subject C1
321015 Oncology and Carcinogenesis
730108 Cancer and related disorders
Abstract Head and neck cancer (HNSCC) is one of the most distressing human cancers, causing pain and affecting the basic survival functions of breathing and swallowing. Mortality rates have not changed despite recent advances in radiotherapy and surgical treatment. We have compared the expression of over 13,000 unique genes in 7 cases of matched HNSCC and normal oral mucosa. Of the 1,260 genes that showed statistically significant differences in expression between normal and tumor tissue at the mRNA level, the three top ranking of the top 5% were selected for further analysis by immunohistochemistry on paraffin sections,. along with the tumor suppressor genes p16 and p53, in a total of 62 patients including 55 for whom >4-year clinical data was available. Using univariate and multivariate survival analysis, we identified SPARC/osteonectin as a powerful independent prognostic marker for short disease-free interval (DFI) (p < 0.002) and poor overall survival (OS) (p = 0.018) of HNSCC patients. In combination with other ECM proteins found in our analysis, PAI-1 and uPA, the association with DFI and OS became even more significant (p < 0.001). Our study represents the first instance of SPARC as an independent prognostic marker in HNSCC.
Keyword Oncology
Sparc
Osteonectin
Upa
Pai-1
Hnscc
Prognosis
Squamous-cell Carcinoma
Growth-factor-beta
Plasminogen-activator
Gene-expression
I Collagen
Protein
Fibroblasts
Tissue
Rich
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
2006 Higher Education Research Data Collection
School of Medicine Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 96 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 95 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Wed, 15 Aug 2007, 16:47:00 EST