Physiological role of carnosine in contracting muscle

Begum, Gulshanara, Cunliffe, Adam and Leveritt, Michael (2005) Physiological role of carnosine in contracting muscle. International Journal of Sport Nutrition and Exercise Metabolism, 15 5: 493-514.

Author Begum, Gulshanara
Cunliffe, Adam
Leveritt, Michael
Title Physiological role of carnosine in contracting muscle
Journal name International Journal of Sport Nutrition and Exercise Metabolism   Check publisher's open access policy
ISSN 1526-484X
Publication date 2005-10-01
Year available 2005
Sub-type Critical review of research, literature review, critical commentary
Volume 15
Issue 5
Start page 493
End page 514
Total pages 22
Editor E. M. Haymes
R. J. Maughan
Place of publication Champaign, Ill
Publisher Human Kinetics
Language eng
Subject C1
730215 Nutrition
321401 Exercise Physiology
Abstract High-intensity exercise leads to reductions in muscle substrates (ATP, PCr, and glycogen) and a subsequent accumulation of metabolites (ADP, Pi, H+, and M2+) with a possible increase in free radical production. These factors independently and collectively have deleterious effects on muscle, with significant repercussions on high-intensity performance or training sessions. The effect of carnosine on overcoming muscle fatigue appears to be related to its ability to buffer the increased H+ concentration following high-intensity work. Carnosine, however, has other roles such as an antioxidant, a metal chelator, a Ca2+ and enzyme regulator, an inhibitor of protein glycosylation and protein-protein cross-linking. To date, only 1 study has investigated the effects of carnosine supplementation (not in pure form) on exercise performance in human subjects and found no improvement in repetitive high-intensity work. Much data has come from in vitro work on animal skeletal muscle fibers or other components of muscle contractile mechanisms. Thus further research needs to be carried out on humans to provide additional understanding on the effects of carnosine in vivo.
Keyword Nutrition & Dietetics
Sport Sciences
Pluripotent Dipeptide
Buffering Agent
Calcium Regulation
Sports Performance
Sarcoplasmic-reticulum Ca2+-atpase
Middle Gluteal Muscle
Human Skeletal-muscle
Ca-release Channels
Rat Soleus Muscle
Oxidative Stress
Cellular Mechanisms
Antioxidative Properties
Intracellular Calcium
Q-Index Code C1
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: 2006 Higher Education Research Data Collection
School of Human Movement and Nutrition Sciences Publications
School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 44 times in Thomson Reuters Web of Science Article | Citations
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Created: Wed, 15 Aug 2007, 16:37:22 EST