Microbial hyaluronic acid production

Chong, B. F., Blank, L., McLaughlin, R. L. and Nielsen, L. K. (2005) Microbial hyaluronic acid production. Applied Microbiology And Biotechnology, 66 4: 341-351. doi:10.1007/s00253-004-1774-4

Author Chong, B. F.
Blank, L.
McLaughlin, R. L.
Nielsen, L. K.
Title Microbial hyaluronic acid production
Journal name Applied Microbiology And Biotechnology   Check publisher's open access policy
ISSN 0175-7598
Publication date 2005-01-01
Year available 2005
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1007/s00253-004-1774-4
Open Access Status Not yet assessed
Volume 66
Issue 4
Start page 341
End page 351
Total pages 11
Editor Alexander Steinbuechel (Editor-in-Chief)
Place of publication New York
Publisher Springer
Language eng
Subject C1
270303 Virology
770804 Control of pests and exotic species
Abstract Hyaluronic acid (HA) is a commercially valuable medical biopolymer increasingly produced through microbial fermentation. Viscosity limits product yield and the focus of research and development has been on improving the key quality parameters, purity and molecular weight. Traditional strain and process optimisation has yielded significant improvements, but appears to have reached a limit. Metabolic engineering is providing new opportunities and HA produced in a heterologous host is about to enter the market. In order to realise the full potential of metabolic engineering, however, greater understanding of the mechanisms underlying chain termination is required.
Keyword Group-a Streptococci
Sodium Hyaluronate
Chemostat Cultures
Virulence Factor
Nadh Oxidase
Human Genome
Q-Index Code C1
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Excellence in Research Australia (ERA) - Collection
2006 Higher Education Research Data Collection
Australian Institute for Bioengineering and Nanotechnology Publications
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Citation counts: TR Web of Science Citation Count  Cited 145 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 167 times in Scopus Article | Citations
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Created: Wed, 15 Aug 2007, 16:27:47 EST