Cadmium-induced nephropathy in the development of high blood pressure

Satarug, S, Nishijo, M, Ujjin, P, Vanavanitkun, Y and Moore, MR (2005) Cadmium-induced nephropathy in the development of high blood pressure. Toxicology Letters, 157 1: 57-68. doi:10.1016/j.toxlet.2005.01.004

Author Satarug, S
Nishijo, M
Ujjin, P
Vanavanitkun, Y
Moore, MR
Title Cadmium-induced nephropathy in the development of high blood pressure
Journal name Toxicology Letters   Check publisher's open access policy
ISSN 0378-4274
Publication date 2005-01-01
Sub-type Article (original research)
DOI 10.1016/j.toxlet.2005.01.004
Open Access Status Not Open Access
Volume 157
Issue 1
Start page 57
End page 68
Total pages 12
Editor J. Kehrer
W. Dekant
Place of publication Clare
Publisher Elsevier Sci Ireland Ltd
Language eng
Subject C1
730210 Environmental health
321299 Public Health and Health Services not elsewhere classified
Abstract In recognition of a central role of the kidney in long-term blood pressure control, we undertook an in-depth analysis of the relationship between blood pressure and kidney damage caused by environmental exposure to the common pollutants cadmium and lead. The subjects were 200 healthy Thais, 16 and 60 years of age (100 female non-smokers, 53 male non-smokers, and 47 male smokers). None of these subjects had been exposed to Cd or Pb in the workplace and their urinary Cd concentrations ranged from 0.4 to 37 nM, whereas their urinary Pb concentrations ranged from 0.1 to 30 nM. The prevalence of high blood pressure was 2%, 8% and 19%, respectively in subjects with low, average and high Cd-burden (linear trend chi(2) = 6.4, P = 0.01). Multiple regression analysis revealed a significant positive association between Cd-burden and blood pressure in male nonsmokers (adjusted beta = 0.31, P = 0.02) and an inverse association between blood pressure and urinary Pb excretion rate in male smokers (adjusted beta = -0.38, P = 0.005). Associations between Cd-burden and nephropathies were evidenced by increases in urinary excretion of beta 2-microglobutin (P = 0.02) and N-acetyl-beta-D-glucosaminidase (P = 0.005) in subjects with high Cd-burden, compared with the subjects with average Cd-burden. In addition, an association between Cd-related nephropathy and high blood pressure was evidenced by a 20% increase in the prevalence of high blood pressure in people with NAG-uria (linear trend chi(2) = 4.3, P = 0.04). Our present study provides first evidence for a possible link between renal tubular damage and dysfunction caused by environmental Cd exposure and increased risk of high blood pressure. (c) 2005 Elsevier Ireland Ltd. All rights reserved.
Keyword Toxic Metals
Environmental Exposure
Essential Hypertension
Beta 2-microglobulin
Japanese General-population
Lead-induced Hypertension
Renal-function Biomarkers
Low-level Cadmium
Environmental Cadmium
20-hydroxyeicosatetraenoic Acid
Occupational Exposure
Hepatic Cyp2a6
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

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Created: Wed, 15 Aug 2007, 16:14:59 EST