NaSi-1 and Sat-1: structure, function and transcriptional regulation of two genes encoding renal proximal tubular sulfate transporters

Lee, A., Dawson, P. A. and Markovich, D. (2005) NaSi-1 and Sat-1: structure, function and transcriptional regulation of two genes encoding renal proximal tubular sulfate transporters. International Journal of Biochemistry & Cell Biology, 37 7: 1350-1356. doi:10.1016/j.biocel.2005.02.013


Author Lee, A.
Dawson, P. A.
Markovich, D.
Title NaSi-1 and Sat-1: structure, function and transcriptional regulation of two genes encoding renal proximal tubular sulfate transporters
Journal name International Journal of Biochemistry & Cell Biology   Check publisher's open access policy
ISSN 1357-2725
Publication date 2005-01-01
Sub-type Article (original research)
DOI 10.1016/j.biocel.2005.02.013
Open Access Status Not Open Access
Volume 37
Issue 7
Start page 1350
End page 1356
Total pages 7
Editor G. Laurent
Place of publication Oxford
Publisher Pergamon-Elsevier Science Ltd
Language eng
Subject C1
270202 Genome Structure
780105 Biological sciences
Abstract Sulfate (SO42-) is an important anion regulating many metabolic and cellular processes. Maintenance Of SO42- homeostasis occurs in the renal proximal tubule via membrane transport proteins. Two SO42- transporters that have been characterized and implicated in regulating serum SO42- levels are: NaSi- 1, a Na+-SO4 (2-) cotransporter located at the brush border membrane and Sat-1, a SO4 (2-) -anion exchanger located on the basolateral membranes of proximal tubular cells. Unlike Sat-1, for which very few studies have looked at regulation of its expression, NaSi- 1 has been shown to be regulated by various hormones and dietary conditions in vivo. To study this further, NaSj- I (SLC13A1) and Sat- I (SLC26A1) gene structures were determined and recent studies have characterized their respective gene promoters. This review presents the current understanding of the transcriptional regulation of NaSj- I and Sat- 1, and describes possible pathogenetic implications which arise as a consequence of altered SO(4)(2-)homeostasis. (c) 2005 Elsevier Ltd. All rights reserved.
Keyword Sulfate Transport
Sulfate Homeostasis
Promoter
Transcriptional Regulation
Biochemistry & Molecular Biology
Cell Biology
Alpha-l-iduronidase
Chromosomal Localization
Tissue Distribution
Expression Cloning
Slc26a1
Nas1
Cdna
Q-Index Code C1

 
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Created: Wed, 15 Aug 2007, 16:11:51 EST