Nuclear translocation of cell-surface receptors: Lessons from fibroblast growth factor

Bryant, David M. and Stow, Jennifer L. (2005) Nuclear translocation of cell-surface receptors: Lessons from fibroblast growth factor. Traffic, 6 10: 947-954. doi:10.1111/j.1600-0854.2005.00332.x


Author Bryant, David M.
Stow, Jennifer L.
Title Nuclear translocation of cell-surface receptors: Lessons from fibroblast growth factor
Journal name Traffic   Check publisher's open access policy
ISSN 1398-9219
Publication date 2005-01-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1111/j.1600-0854.2005.00332.x
Volume 6
Issue 10
Start page 947
End page 954
Total pages 8
Place of publication Oxford
Publisher Blackwell Publishing
Language eng
Subject C1
270103 Protein Targeting and Signal Transduction
780106 Political science and public policy
Abstract The nuclear localization of a number of growth factors, cytokine ligands and their receptors has been reported in various cell lines and tissues. These include members of the fibroblast growth factor (FGF), epidermal growth factor and growth hormone families. Accordingly, a number of nuclear functions have begun to emerge for these protein families. The demonstration of functional interactions of these proteins with the nuclear import machinery has further supported their functions as nuclear signal transducers. Here, we review the membrane- trafficking machinery and pathways demonstrated to regulate this cell surface to nucleus-trafficking event and highlight the many remaining unanswered questions. We focus on the FGF family, which is providing many of the clues as to the process of this unusual phenomenon.
Keyword Fgf
Growth Factors
Nuclear Translocation
Signalling
Trafficking
Cell Biology
Pathway Mediates Activation
Vascular Endothelial-cells
Fgfr1 Signaling Infs
Protein-kinase-c
Heparan-sulfate
Intracellular-transport
Human Astrocytes
Angiotensin-ii
Localization
Cytosol
Q-Index Code C1

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Excellence in Research Australia (ERA) - Collection
2006 Higher Education Research Data Collection
Institute for Molecular Bioscience - Publications
 
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Created: Wed, 15 Aug 2007, 15:56:28 EST