Interaction between conventional dendritic cells and natural killer cells is integral to the activation of effective antiviral immunity

Andoniou, C. E., van Dommelen, S. L. H., Voigt, V., Andrews, D. M., Brizard, G., Asselin-Paturel, C., Delale, T., Stacey, K. J., Trinchieri, G. and Degli-Esposti, M. A. (2005) Interaction between conventional dendritic cells and natural killer cells is integral to the activation of effective antiviral immunity. Nature Immunology, 6 10: 1011-1019. doi:10.1038/ni1244


Author Andoniou, C. E.
van Dommelen, S. L. H.
Voigt, V.
Andrews, D. M.
Brizard, G.
Asselin-Paturel, C.
Delale, T.
Stacey, K. J.
Trinchieri, G.
Degli-Esposti, M. A.
Title Interaction between conventional dendritic cells and natural killer cells is integral to the activation of effective antiviral immunity
Journal name Nature Immunology   Check publisher's open access policy
ISSN 1529-2908
Publication date 2005-01-01
Sub-type Article (original research)
DOI 10.1038/ni1244
Volume 6
Issue 10
Start page 1011
End page 1019
Total pages 9
Place of publication New York
Publisher Nature Publishing Group
Language eng
Subject C1
320202 Cellular Immunology
730101 Infectious diseases
Abstract Dendritic cells (DCs) regulate various aspects of innate immunity, including natural killer (NK) cell function. Here we define the mechanisms involved in DC - NK cell interactions during viral infection. NK cells were efficiently activated by murine cytomegalovirus ( MCMV) - infected CD11b(+) DCs. NK cell cytotoxicity required interferon-alpha and interactions between the NKG2D activating receptor and NKG2D ligand, whereas the production of interferon-gamma by NK cells relied mainly on DC-derived interleukin 18. Although Toll-like receptor 9 contributes to antiviral immunity, we found that signaling pathways independent of Toll-like receptor 9 were important in generating immune responses to MCMV, including the production of interferon-alpha and the induction of NK cell cytotoxicity. Notably, adoptive transfer of MCMV-activated CD11b(+) DCs resulted in improved control of MCMV infection, indicating that these cells participate in controlling viral replication in vivo.
Keyword Immunology
Murine Cytomegalovirus-infection
Colony-stimulating Factor
Ifn-alpha-beta
Nk Cells
Nkg2d Receptor
In-vivo
Viral-infections
Interferon-alpha/beta
Cytokine Responses
Tumor-immunity
Q-Index Code C1

 
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Created: Wed, 15 Aug 2007, 15:54:14 EST