Sequence, circulating levels, and expression of C-type natriuretic peptide in a euryhaline elasmobranch, Carcharhinus leucas

Anderson, W. G., Hyodo, S., Tsukada, T., Meischke, L., Pillans, R. D., Good, J. P., Takei, Y., Cramb, G., Franklin, C. E. and Hazon, Neil (2005) Sequence, circulating levels, and expression of C-type natriuretic peptide in a euryhaline elasmobranch, Carcharhinus leucas. General And Comparative Endocrinology, 144 1: 90-98. doi:10.1016/j.ygcen.2005.04.013


Author Anderson, W. G.
Hyodo, S.
Tsukada, T.
Meischke, L.
Pillans, R. D.
Good, J. P.
Takei, Y.
Cramb, G.
Franklin, C. E.
Hazon, Neil
Title Sequence, circulating levels, and expression of C-type natriuretic peptide in a euryhaline elasmobranch, Carcharhinus leucas
Journal name General And Comparative Endocrinology   Check publisher's open access policy
ISSN 0016-6480
Publication date 2005-10-01
Sub-type Article (original research)
DOI 10.1016/j.ygcen.2005.04.013
Volume 144
Issue 1
Start page 90
End page 98
Total pages 9
Editor Henderson, Dr Ian W (Editor-in-Chief)
Dores, Dr R.M. (Editor-in-Chief)
Place of publication New York
Publisher Academic Press
Language eng
Subject C1
270603 Animal Physiology - Systems
780105 Biological sciences
Abstract The present study has examined expression and circulating levels of C-type natriuretic peptide (CNP) in the euryhaline bull shark, Carcharhinus leucas. Complementary DNA and deduced amino acid sequence for CNP in C leucas were determined by RACE methods. Homology of CNP amino acid sequence in C. leucas was high both for proCNP and for mature CNP when compared with previously identified elasmobranch CNPs. Mature CNP sequence in C. leucas was identical to that in Triakis seyllia and Seyliorhinus canicula. Levels of expression of CNP mRNA were significantly decreased in the atrium but did not change in either the brain or ventricle following acclimation to a SW environment. However, circulating levels of CNP significantly increased from 86.0 +/- 7.9 fmol ml(-1) in FW to 144.9 +/- 19.5 fmol ml(-1) in SW. The results presented demonstrate that changes in environmental salinity influences both synthesis of CNP from the heart and also circulating levels in C. leucas. Potential stimulus for release and modes of action are discussed. (c) 2005 Elsevier Inc. All rights reserved.
Keyword Endocrinology & Metabolism
Euryhaline
Bull Shark
Carcharhinus
Natriuretic Peptide
Renin-angiotensin System
Rectal Gland-function
Trout Oncorhynchus-mykiss
Lesser-spotted Dogfish
Volume Expansion
Neurohypophyseal Hormones
Molecular Evolution
Squalus-acanthias
Triakis-scyllia
Fresh-water
Q-Index Code C1

 
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Created: Wed, 15 Aug 2007, 15:49:55 EST