Independent roles of calcium and voltage-dependent potassium currents in controlling spike frequency adaptation in lateral amygdala pyramidal neurons

Faber, E. S. L. and Sah, P. (2005) Independent roles of calcium and voltage-dependent potassium currents in controlling spike frequency adaptation in lateral amygdala pyramidal neurons. European Journal of Neuroscience, 22 7: 1627-1635. doi:10.1111/j.1460-9568.2005.04357.x


Author Faber, E. S. L.
Sah, P.
Title Independent roles of calcium and voltage-dependent potassium currents in controlling spike frequency adaptation in lateral amygdala pyramidal neurons
Journal name European Journal of Neuroscience   Check publisher's open access policy
ISSN 0953-816X
Publication date 2005-01-01
Sub-type Article (original research)
DOI 10.1111/j.1460-9568.2005.04357.x
Volume 22
Issue 7
Start page 1627
End page 1635
Total pages 9
Editor Barry J. Everitt
Christopher E. Henderson
Place of publication Oxford
Publisher Blackwell Publishing
Collection year 2005
Language eng
Subject C1
320702 Central Nervous System
730104 Nervous system and disorders
Abstract The calcium-dependent afterhyperpolarization (AHP) that follows trains of action potentials is responsible for controlling action potential firing patterns in many neuronal cell types. We have previously shown that the slow AHP contributes to spike frequency adaptation in pyramidal neurons in the rat lateral amygdala. In addition, a dendritic voltage-gated potassium current mediated by Kv1.2-containing channels also suppresses action potential firing in these neurons. In this paper we show that this voltage-gated potassium current and the slow AHP act together to control spike frequency adaptation in lateral amygdala pyramidal neurons. The two currents have similar effects on action potential number when firing is evoked either by depolarizing current injections or by synaptic stimulation. However, they differ in their control of firing frequency, with the voltage-gated potassium current but not the slow AHP determining the initial frequency of action potential firing. This dual mechanism of controlling firing patterns is unique to lateral amygdala neurons and is likely to contribute to the very low levels of firing seen in lateral amygdala neurons in vivo.
Keyword Acetylcholine
Fear
Learning
Memory
Rat
Neurosciences
Cat Sensorimotor Cortex
Ca2+-activated K+ Current
Rat Prefrontal Cortex
In-vitro
Slow Afterdepolarization
Synaptic-transmission
Hippocampal-neurons
Neocortical Neurons
Channels
Excitability
Q-Index Code C1

 
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Created: Wed, 15 Aug 2007, 15:49:41 EST