Regulation of adult olfactory neurogenesis by insulin-like growth factor-I

McCurdy, RD, Feron, F, McGrath, JJ and Mackay-Sim, A (2005) Regulation of adult olfactory neurogenesis by insulin-like growth factor-I. European Journal of Neuroscience, 22 7: 1581-1588. doi:10.1111/j.1460-9568.2005.04355.x


Author McCurdy, RD
Feron, F
McGrath, JJ
Mackay-Sim, A
Title Regulation of adult olfactory neurogenesis by insulin-like growth factor-I
Journal name European Journal of Neuroscience   Check publisher's open access policy
ISSN 0953-816X
Publication date 2005-01-01
Sub-type Article (original research)
DOI 10.1111/j.1460-9568.2005.04355.x
Volume 22
Issue 7
Start page 1581
End page 1588
Total pages 8
Editor B. Everitt
C. E. Henderson
Place of publication UK
Publisher Blackwell Publishing Ltd
Collection year 2005
Language eng
Subject C1
321021 Psychiatry
730211 Mental health
Abstract Insulin-like growth factor-I (IGF-I) has multiple effects within the developing nervous system but its role in neurogenesis in the adult nervous system is less clear. The adult olfactory mucosa is a site of continuing neurogenesis that expresses IGF-I, its receptor and its binding proteins. The aim of the present study was to investigate the roles of IGF-I in regulating proliferation and differentiation in the olfactory mucosa. The action of IGF-I was assayed in serum-free culture combined with bromodeoxyuridine-labelling of proliferating cells and immunochemistry for specific cell types. IGF-I and its receptor were expressed by globose basal cells (the neuronal precursor) and by olfactory neurons. IGF-I reduced the numbers of proliferating neuronal precursors, induced their differentiation into neurons and promoted morphological differentiation of neurons. The evidence suggests that IGF-I is an autocrine and/or paracrine signal that induces neuronal precursors to differentiate into olfactory sensory neurons. These effects appear to be similar to the cellular effects of IGF-I in the developing nervous system.
Keyword Neurosciences
Insulin-like Growth Factor-i Receptor-alpha
Olfactory Receptor Neuron
Olfactory Ensheathing Cell
Neurogenesis
Differentiation
Rodent
Globose Basal-cells
Central-nervous-system
Igf-i
Ensheathing Cells
Dentate Gyrus
Factor-alpha
Epithelium
Receptor
Neuron
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2006 Higher Education Research Data Collection
School of Medicine Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 29 times in Thomson Reuters Web of Science Article | Citations
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Created: Wed, 15 Aug 2007, 15:49:38 EST