Deep dermal burn injury results in scarless wound healing in the ovine fetus

Fraser, John F., Cuttle, Leila, Kempf, Margit, Phillips, Gael E., O'Rourke, Peter K., Choo, Kelvin, Hayes, Mark T. and Kimble, Roy M. (2005) Deep dermal burn injury results in scarless wound healing in the ovine fetus. Wound Repair and Regeneration, 13 2: 189-197. doi:10.1111/j.1067-1927.2005.130210.x


Author Fraser, John F.
Cuttle, Leila
Kempf, Margit
Phillips, Gael E.
O'Rourke, Peter K.
Choo, Kelvin
Hayes, Mark T.
Kimble, Roy M.
Title Deep dermal burn injury results in scarless wound healing in the ovine fetus
Journal name Wound Repair and Regeneration   Check publisher's open access policy
ISSN 1067-1927
1524-475X
Publication date 2005-01-01
Sub-type Article (original research)
DOI 10.1111/j.1067-1927.2005.130210.x
Volume 13
Issue 2
Start page 189
End page 197
Total pages 9
Editor W. J. Lindblad
Place of publication Malden, U.S.A.
Publisher Blackwell Publishing
Language eng
Subject C1
321019 Paediatrics
730109 Surgical methods and procedures
Abstract Early to mid-term fetuses heal cutaneous incisional wounds without scars; however, fetal response to burn injury has not been ascertained. We present a fetal model of thermal injury and subsequent analysis of fetal and lamb response to burn injury. A reproducible deep dermal burn injury was created in the fetus by application of water at 66 degrees C for 7 seconds, and at 82 degrees C for 10 seconds to the lamb. Macroscopically, the area of fetal scald was undetectable from day 7 post injury, while all lamb scalds were readily identified and eventually healed with scarring. Using a five-point histopathology scoring system for alteration in tissue morphology, differences were detected between control and scalded skin at all stages in lamb postburn, but no difference was detected in the fetal model after day 7. There were also large differences in content of alpha-smooth muscle actin and transforming growth factor-beta 1 between control and scalded lamb and these differences were statistically significant at day 14 (P < 0.01). This novel model of fetal and lamb response to deep dermal injury indicates that the fetus heals a deep burn injury in a scarless fashion. Further elucidation of this specific fetal process of burn injury repair may lead to improved outcome for patients with burn injury.
Keyword Cell Biology
Dermatology
Medicine, Research & Experimental
Surgery
Growth-factor-beta
Fetal Sheep Wounds
Myofibroblast Persistence
Granulation-tissue
Skin
Expression
Fibroblasts
Transition
Apoptosis
Features
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
2006 Higher Education Research Data Collection
School of Medicine Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 19 times in Thomson Reuters Web of Science Article | Citations
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Created: Wed, 15 Aug 2007, 15:42:01 EST