Regulatory T-cells infiltrate periodontal disease tissues

Nakajima, T., Ueki-Maruyama, K., Oda, T., Ohsawa, Y., Ito, H., Seymour, G. J. and Yamazaki, K. (2005) Regulatory T-cells infiltrate periodontal disease tissues. Journal of Dental Research, 84 7: 639-643. doi:10.1177/154405910508400711

Author Nakajima, T.
Ueki-Maruyama, K.
Oda, T.
Ohsawa, Y.
Ito, H.
Seymour, G. J.
Yamazaki, K.
Title Regulatory T-cells infiltrate periodontal disease tissues
Journal name Journal of Dental Research   Check publisher's open access policy
ISSN 0022-0345
Publication date 2005-07-01
Sub-type Article (original research)
DOI 10.1177/154405910508400711
Open Access Status
Volume 84
Issue 7
Start page 639
End page 643
Total pages 5
Place of publication Chicago, Ill. U.S.A
Publisher Sage
Language eng
Subject C1
320899 Dentistry not elsewhere classified
730112 Oro-dental and disorders
1105 Dentistry
Abstract CD4(+) CD25(+) regulatory T ( Tr) cells are critical in regulating the immune response and thereby play an important role in the defense against infection and control of autoimmune diseases. Our previous studies demonstrated the involvement of autoimmune responses in periodontitis. The aim of this study was to identify CD4(+) CD25(+) Tr cells in periodontitis tissues and compare them with those in gingivitis tissues. Immunohistological analysis of CD4, CD25, and CTLA- 4 and the gene expression analysis of FOXP3, TGF- beta 1, and IL-10 on gingival biopsies revealed the presence of CD4(+) CD25(+) Tr cells in all tissues. In periodontitis, the percentage of CD4(+) CD25(+) Tr cells increased with increasing proportions of B-cells relative to T- cells. FOXP3, a characteristic marker for CD4(+) CD25(+) Tr cells, TGF- beta 1 and IL-10 were expressed more highly in periodontitis compared with gingivitis. These findings suggest that CD4(+) CD25(+) Tr cells and possibly other regulatory T- cell populations do exist and may play regulatory roles in periodontal diseases.
Keyword Dentistry, Oral Surgery & Medicine
Regulatory T-cell
Periodontal Disease
Real-time Pcr
Immunohistological Analysis
Gingival Tissues
Antigen 4
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
2006 Higher Education Research Data Collection
School of Dentistry Publications
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Citation counts: TR Web of Science Citation Count  Cited 78 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 92 times in Scopus Article | Citations
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Created: Wed, 15 Aug 2007, 15:32:21 EST